• Publications
  • Influence
A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
TLDR
The findings suggest that QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome. Expand
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.
TLDR
Analysis of rat L6 myotubes treated with the PPARdelta subtype-selective agonist, GW501516, by the Affymetrix oligonucleotide microarrays revealed that PPardelta controls fatty acid oxidation by regulating genes involved in fatty acid transport, beta-oxidation, and mitochondrial respiration. Expand
Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome
TLDR
Analysis of rat L6 myotubes treated with the PPARδ subtype-selective agonist, GW501516, by the Affymetrix oligonucleotide microarrays revealed that PPAR Δ is pivotal to control the program for fatty acid oxidation in the skeletal muscle, thereby ameliorating obesity and insulin resistance through its activation in obese animals. Expand
Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.
TLDR
It is suggested that this VLDL receptor may mediate uptake of apolipoprotein E-containing lipoproteins enriched with triglyceride in nonhepatic tissues that are active in fatty acid metabolism. Expand
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.
TLDR
S2P defines a new family of polytopic membrane proteins that contain an HEXXH sequence characteristic of zinc metalloproteases that cleaves proteins within transmembrane segments. Expand
Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.
TLDR
It is proposed that S1P is the sterol-regulated protease that controls lipid metabolism in animal cells, and pCMV-PLAP-BP2 is prepared, which encodes a fusion protein that contains placental alkaline phosphatase (PLAP) in the ER lumen flanked by cleavage sites for signal peptidase and S 1P. Expand
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
TLDR
The data suggest that Wnt/LRP5 signaling contributes to the glucose-induced insulin secretion in the islets, which is also required for normal cholesterol and glucose metabolism. Expand
Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.
TLDR
Although the 5'-flanking region of the VLDL receptor gene contains two copies of a sterol regulatory element-1 like sequence, the levels of mRNA for the receptor in THP-1 human monocytic leukemia cells were unchanged by sterols. Expand
Angiopoietin-related growth factor antagonizes obesity and insulin resistance
TLDR
AGF is established as a new hepatocyte-derived circulating factor that counteracts obesity and related insulin resistance and is protected from high-fat diet–induced obesity, insulin resistance, and nonadipose tissue steatosis. Expand
Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment
TLDR
Using H-Ras-SREBP-2 fusion proteins, it is shown that the NH2-segment is released from membranes by two sequential cleavages and enters the nucleus and activates genes controlling cholesterol synthesis and uptake. Expand
...
1
2
3
4
5
...