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Global Epigenomic Reconfiguration During Mammalian Brain Development
Introduction Several lines of evidence point to a key role for dynamic epigenetic changes during brain development, maturation, and learning. DNA methylation (mC) is a stable covalent modificationExpand
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The Polycomb group protein EZH2 directly controls DNA methylation
This corrects the article DOI: 10.1038/nature04431
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Epigenetic modifications and human disease
Epigenetics is one of the most rapidly expanding fields in biology. The recent characterization of a human DNA methylome at single nucleotide resolution, the discovery of the CpG island shores, theExpand
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Non-coding RNAs in human disease
  • M. Esteller
  • Biology, Medicine
  • Nature Reviews Genetics
  • 18 November 2011
The relevance of the non-coding genome to human disease has mainly been studied in the context of the widespread disruption of microRNA (miRNA) expression and function that is seen in human cancer.Expand
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Epigenetic differences arise during the lifetime of monozygotic twins.
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities toExpand
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A gene hypermethylation profile of human cancer.
We are in an era where the potential exists for deriving comprehensive profiles of DNA alterations characterizing each form of human cancer. Such profiles would provide invaluable insight intoExpand
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The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
Transcriptional repression mechanisms have emerged as one of the crucial processes for the downregulation of E-cadherin expression during development and tumour progression. Recently, severalExpand
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A Landscape of Pharmacogenomic Interactions in Cancer
Summary Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies inExpand
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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
BACKGROUND The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a promoter; methylation of theExpand
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Cancer epigenomics: DNA methylomes and histone-modification maps
  • M. Esteller
  • Biology, Medicine
  • Nature Reviews Genetics
  • 1 April 2007
An altered pattern of epigenetic modifications is central to many common human diseases, including cancer. Many studies have explored the mosaic patterns of DNA methylation and histone modificationExpand
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