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SAP kinase activity

Known as: SAPK, stress-activated kinase activity, stress-activated protein kinase activity 
Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to… 
National Institutes of Health

Papers overview

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2011
2011
Interferon alpha regulates MAPK and STAT1 pathways in human hepatoma cells
BackgroundSignaling events triggered by interferon (IFN) account for the molecular mechanisms of antiviral effect. JAK-STAT… 
Highly Cited
2007
Highly Cited
2007
Saponins from Tribulus terrestris L. Are Less Toxic for Normal Human Fibroblasts than for Many Cancer Lines: Influence on Apoptosis and Proliferation
The objective of the study was to explore the influence of saponins derived from Tribulus terrestris L. (TT) on normal human skin… 
2004
2004
Inhibition of Monocytic Interleukin-12 Production by Candida albicans via Selective Activation of ERK Mitogen-Activated Protein Kinase
ABSTRACT Our previous data demonstrated that live Candida albicans inhibits interleukin-12 (IL-12) production by human monocytes… 
Highly Cited
2003
Highly Cited
2003
JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease
JNK/SAPK has been implicated in the pathogenesis of Alzheimer's disease, but the upstream cascade leading to JNK/SAPK activation… 
2003
2003
SAPK/JNK regulates cdc2/cyclin B kinase through phosphorylation and inhibition of cdc25c.
Highly Cited
2001
Highly Cited
2001
Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway.
Low levels of H2O2 can induce cellular resistance to subsequent higher levels of H2O2. By using human U937 leukemia cells, it was… 
Highly Cited
1998
Highly Cited
1998
Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1beta…
The extracellular microenvironment of tumors differs from that of most normal tissues. Many tumors have relatively acidic… 
Highly Cited
1998
Highly Cited
1998
Differential expression of SAPK isoforms in the rat brain. An in situ hybridisation study in the adult rat brain and during post-natal development.
Highly Cited
1997
Highly Cited
1997
Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes
The dual specific kinase SAPK/ERK1 kinase (SEK1; mitogen-activated protein kinase kinase 4/Jun NH2 terminal kinase [ JNK] kinase… 
Highly Cited
1997
Highly Cited
1997
Nitric oxide modulates the c-Jun N-terminal kinase/stress-activated protein kinase activity through activating c-Jun N-terminal kinase kinase.
Nitric oxide is a signaling molecule that has a broad range of physiological functions, including neurotransmission, macrophage… 
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