Interferon alpha regulates MAPK and STAT1 pathways in human hepatoma cells

@inproceedings{Zhao2010InterferonAR,
  title={Interferon alpha regulates MAPK and STAT1 pathways in human hepatoma cells},
  author={L J Zhao and Xian Hua and Sheng-Fei He and H. C. Ren and Zhong-tian Qi},
  booktitle={Virology Journal},
  year={2010}
}
Signaling events triggered by interferon (IFN) account for the molecular mechanisms of antiviral effect. JAK-STAT pathway plays a critical role in IFN signaling, and other pathways are also implicated in IFN-mediated antiviral effect. Changes in mitogen-activated protein kinase (MAPK) and STAT1 pathways were evaluated in human hepatoma cells Huh7 and HepG2 upon IFN alpha treatment. Phosphorylation of ERK was significantly and specifically up-regulated, whereas enhanced phosphorylation of… CONTINUE READING
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