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Biofilm Formation by the Fungal PathogenCandida albicans: Development, Architecture, and Drug Resistance
- J. Chandra, D. Kuhn, P. Mukherjee, L. Hoyer, T. McCormick, M. Ghannoum
- Medicine, BiologyJournal of bacteriology
- 15 September 2001
The studies described here form the basis for investigations into the molecular mechanisms of Candida biofilm biology and antifungal resistance and provide the means to design novel therapies for biofilm-based infections.
Characterization of the Oral Fungal Microbiome (Mycobiome) in Healthy Individuals
This is the first study that identified the “basal mycobiome” of healthy individuals, and provides the basis for a detailed characterization of the oral myCobiome in health and disease.
Antifungal Susceptibility of Candida Biofilms: Unique Efficacy of Amphotericin B Lipid Formulations and Echinocandins
- D. Kuhn, T. George, J. Chandra, P. Mukherjee, M. Ghannoum
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 June 2002
The data show that Candida biofilms show unique susceptibilities to echinocandins and AMB lipid formulations, which differed with each agent.
Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance
The mode of action of antifungals and their mechanisms of resistance are discussed, and an attempt is made to discuss the correlation between fungal and bacterial resistance.
Potential role of phospholipases in virulence and fungal pathogenesis.
- M. Ghannoum
- Biology, MedicineClinical microbiology reviews
Data indicate that phospholipase B is essential for candidal virulence, and early data suggest that direct host cell damage and lysis are the main mechanisms contributing to fungal virulence.
Comparison of Biofilms Formed by Candidaalbicans and Candidaparapsilosis on Bioprosthetic Surfaces
- D. Kuhn, J. Chandra, P. Mukherjee, M. Ghannoum
- Medicine, BiologyInfection and Immunity
- 1 February 2002
The data show that C. albicans produces quantitatively larger and qualitatively more complex biofilms than other species, in particular, C. parapsilosis.
Mechanism of Fluconazole Resistance in Candida albicans Biofilms: Phase-Specific Role of Efflux Pumps and Membrane Sterols
These studies suggest that multicomponent, phase-specific mechanisms are operative in antifungal resistance of fungal biofilms.
Antifungal Resistance of Candidal Biofilms Formed on Denture Acrylic in vitro
- J. Chandra, P. Mukherjee, +4 authors M. Ghannoum
- Chemistry, MedicineJournal of dental research
- 1 March 2001
Results obtained by means of the biofilm model show that biofilm-associated C. albicans cells, compared with cells grown in planktonic form, are resistant to antifungals used to treat denture stomatitis.
Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and candida…
- J. Rex, M. Pfaller, +8 authors A. Barry
- MedicineClinical infectious diseases : an official…
- 1 February 1997
The conceptual framework underlying interpretation of antimicrobial susceptibility testing results is examined and these ideas are used to drive analysis of data packages developed by the respective manufacturers that correlate fluconazole and itraconazole MICs with outcome of candidal infections.
A large-scale North American study of fungal isolates from nails: the frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns.
- M. Ghannoum, R. Hajjeh, +20 authors B. Elewski
- MedicineJournal of the American Academy of Dermatology
- 1 October 2000
The higher frequency of onychomycosis in this study may confirm the suspected increase in incidence of disease in North America.