Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
- D. Klionsky, H. Abeliovich, R. Deter
- BiologyAutophagy
- 16 February 2008
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Mitochondrial abnormalities in Alzheimer disease
- George Perry, K. Hirai, G. Aliev, A. Nunomura, S. Siedlak, Mark A. Smith
- BiologyNeurobiology of Aging
- 1 May 2000
Morphometric analysis showed that mitochondria are significantly reduced in Alzheimer's disease, and the relationship shown here between the site and extent of mitochondrial abnormalities and oxidative damage suggests an intimate and early association between these features in dementia.
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
- Xinglong Wang, B. Su, Xiongwei Zhu
- BiologyJournal of Neuroscience
- 15 July 2009
DLP1 overexpression, likely through repopulation of neuronal processes with mitochondria, prevented ADDL-induced synaptic loss, suggesting that abnormal mitochondrial dynamics plays an important role in ADDL -induced synaptic abnormalities.
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.
- M. Smith, P. Harris, L. Sayre, George Perry
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 2 September 1997
It is found, using a modified histochemical technique that relies on the formation of mixed valence iron complexes, that redox-active iron is associated with the senile plaques and neurofibrillary tangles-the pathological hallmark lesions of Alzheimer disease.
Oxidative Damage Is the Earliest Event in Alzheimer Disease
- A. Nunomura, George Perry, Mark A. Smith
- BiologyJournal of Neuropathology and Experimental…
- 1 August 2001
The observations indicate that increased oxidative damage is an early event in AD that decreases with disease progression and lesion formation and suggest that AD is associated with compensatory changes that reduce damage from reactive oxygen.
Oxidative stress in Alzheimer's disease.
- M. Smith, C. Rottkamp, A. Nunomura, A. Raina, George Perry
- BiologyBiochimica et Biophysica Acta
- 26 July 2000
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
- Mark A. Smith, Peggy L. Richey Harris, L. Sayre, J. Beckman, George Perry
- Biology, ChemistryJournal of Neuroscience
- 15 April 1997
There is strong evidence that peroxynitrite is involved in oxidative damage of Alzheimer’s disease, and the widespread occurrence of nitrotyrosine in neurons suggests that oxidative damage is not restricted to long-lived polymers such as NFTs, but instead reflects a generalized oxidative stress that is important in disease pathogenesis.
RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease
- A. Nunomura, George Perry, Mark A. Smith
- BiologyJournal of Neuroscience
- 15 March 1999
Surprisingly, the oxidized nucleoside was associated predominantly with RNA because immunoreaction was diminished greatly by preincubation in RNase but only slightly by DNase, the first evidence of increased RNA oxidation restricted to vulnerable neurons in AD.
Oxidative stress and mitochondrial dysfunction in Alzheimer's disease.
- Xinglong Wang, Wenzhang Wang, Li Li, George Perry, Hyoung-Gon Lee, Xiongwei Zhu
- BiologyBiochimica et Biophysica Acta
- 1 August 2014
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons.
- J. Zhang, George Perry, T. Montine
- BiologyAmerican Journal of Pathology
- 1 May 1999
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