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Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
TLDR
Mice deficient in mGluRl have severe motor coordination and spatial learning deficits, and show impaired cerebellar long-term depression and hippocampal mossy fibre long- term potentiation, and should be valuable models for studying synaptic plasticity.
Different Fear States Engage Distinct Networks within the Intercalated Cell Clusters of the Amygdala
TLDR
A distinctive participation of ITC clusters to different fear states and the underlying anatomical circuitries are revealed, shedding new light on ITC networks and providing a novel framework to elucidate their role in fear expression and extinction.
Activation of the extracellular signal‐regulated kinase 2 by metabotropic glutamate receptors
TLDR
Findings raise the possibility of a MAPK cascade involvement in glutamate‐dependent neuronal plasticity mediated through stimulation of mGluRs in the control of cellular responses to changes in the external environment.
Metabotropic glutamate receptors
TLDR
The distinct regional, cellular and subcellular distribution of mGlus in the brain will be discussed in view of their relationship to neurotransmitter release sites and of possible functional implications.
Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
TLDR
Recent advancements in the pharmacology and concepts about the intracellular transduction and pathophysiological role of mGlu1 receptors are discussed and earlier data is reviewed in view of these novel findings.
Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus
TLDR
The postsynaptic interneuron type-specific expression of the high-efficacy presynaptic mGluR8 in both putative glutamatergic and in identified GABAergic terminals predicts a role in adjusting the activity of interneurons depending on the level of network activity.
Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8
TLDR
The two isoforms of each receptor have identical pharmacological profiles when expressed in heterologous systems, despite structural differences in the carboxyl‐terminal domains.
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