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Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
Mice deficient in mGluRl have severe motor coordination and spatial learning deficits, and show impaired cerebellar long-term depression and hippocampal mossy fibre long- term potentiation, and should be valuable models for studying synaptic plasticity.
Metabotropic glutamate receptors: From the workbench to the bedside
Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS
Different Fear States Engage Distinct Networks within the Intercalated Cell Clusters of the Amygdala
A distinctive participation of ITC clusters to different fear states and the underlying anatomical circuitries are revealed, shedding new light on ITC networks and providing a novel framework to elucidate their role in fear expression and extinction.
Activation of the extracellular signal‐regulated kinase 2 by metabotropic glutamate receptors
- F. Ferraguti, Barbara Baldani-Guerra, M. Corsi, S. Nakanishi, C. Corti
- Biology, ChemistryThe European journal of neuroscience
- 1 June 1999
Findings raise the possibility of a MAPK cascade involvement in glutamate‐dependent neuronal plasticity mediated through stimulation of mGluRs in the control of cellular responses to changes in the external environment.
Cell-Type-Specific Recruitment of Amygdala Interneurons to Hippocampal Theta Rhythm and Noxious Stimuli In Vivo
Metabotropic glutamate receptors
The distinct regional, cellular and subcellular distribution of mGlus in the brain will be discussed in view of their relationship to neurotransmitter release sites and of possible functional implications.
Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
Recent advancements in the pharmacology and concepts about the intracellular transduction and pathophysiological role of mGlu1 receptors are discussed and earlier data is reviewed in view of these novel findings.
Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus
The postsynaptic interneuron type-specific expression of the high-efficacy presynaptic mGluR8 in both putative glutamatergic and in identified GABAergic terminals predicts a role in adjusting the activity of interneurons depending on the level of network activity.
Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8
The two isoforms of each receptor have identical pharmacological profiles when expressed in heterologous systems, despite structural differences in the carboxyl‐terminal domains.