Ribosomal Protein S6 Kinases, 90-kDa

Known as: p90(rsk), Ribosomal Protein S6 Kinase, 90-kDa, MAPKAPK1 
A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular… (More)
National Institutes of Health

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In BloodProcess of secretionRibosomal Protein S6 Kinaseantagonists & inhibitors
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Broader (1)

Protein-Serine-Threonine Kinases

Narrower (2)

mitogen and stress-activated protein kinase 1ribosomal protein S6 kinase 2

Papers overview

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2009
2009
p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.
Chaperonin containing TCP-1 (CCT) is a large multisubunit complex that mediates protein folding in eukaryotic cells. CCT… (More)
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Highly Cited
2003
Highly Cited
2003
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
BACKGROUND Tuberous Sclerosis Complex (TSC) is a genetic disorder that occurs through the loss of heterozygosity of either TSC1… (More)
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Highly Cited
2001
Highly Cited
2001
Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice.
The p90 ribosomal S6 kinase (RSK), a cytosolic substrate for the extracellular signal-regulated kinase (ERK), is involved in… (More)
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Highly Cited
2001
Highly Cited
2001
Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation.
Proper chromosome condensation requires the phosphorylation of histone and nonhistone chromatin proteins. We have used an in… (More)
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2000
2000
Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras.
Reactive oxygen species and growth factors stimulate similar intracellular signal transduction events including activation of Src… (More)
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Highly Cited
1997
Highly Cited
1997
The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro.
Nuclear factor kappaB (NF-kappaB) is a eukaryotic member of the Rel family of transcription factors whose biological activity is… (More)
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Highly Cited
1997
Highly Cited
1997
The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.
The protein kinase C (PKC) inhibitors Ro 318220 and GF 109203X have been used in over 350 published studies to investigate the… (More)
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Highly Cited
1996
Highly Cited
1996
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase.
The substrate specificity of protein kinase-B alpha (PKBalpha, also known as RAC kinase or Akt) was investigated using synthetic… (More)
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Highly Cited
1996
Highly Cited
1996
Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.
Each of the three known mammalian 90-kDa S6 kinase (pp90(rsk)) isoforms (RSK1, RSK2, and RSK3) was expressed in transfected cells… (More)
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Highly Cited
1993
Highly Cited
1993
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
The beta-isoform of glycogen synthase kinase-3 (GSK3 beta) isolated from rabbit skeletal muscle was inactivated 90-95% following… (More)
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