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Ribosomal Protein S6 Kinases, 90-kDa

Known as: p90(rsk), Ribosomal Protein S6 Kinase, 90-kDa, MAPKAPK1 
A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular… Expand
National Institutes of Health

Related topics

Related topics

11 relations
In BloodProcess of secretionRibosomal Protein S6 Kinaseantagonists & inhibitors
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Broader (1)

Protein-Serine-Threonine Kinases

Narrower (2)

mitogen and stress-activated protein kinase 1ribosomal protein S6 kinase 2

Papers overview

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Highly Cited
2003
Highly Cited
2003
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
BACKGROUND Tuberous Sclerosis Complex (TSC) is a genetic disorder that occurs through the loss of heterozygosity of either TSC1… Expand
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Highly Cited
2001
Highly Cited
2001
Chromatin-associated Protein Phosphatase 1 Regulates Aurora-B and Histone H3 Phosphorylation*
Proper chromosome condensation requires the phosphorylation of histone and nonhistone chromatin proteins. We have used an in… Expand
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Highly Cited
1999
Highly Cited
1999
Activation of the MAPK Signal Cascade by the Neural Cell Adhesion Molecule L1 Requires L1 Internalization*
L1-mediated axon growth involves intracellular signaling, but the precise mechanisms involved are not yet clear. We report a role… Expand
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Highly Cited
1999
Highly Cited
1999
A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1
Activation of the various mitogen-activated protein (MAP) kinase pathways converts many different extracellular stimuli into… Expand
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Highly Cited
1998
Highly Cited
1998
A link between MAP kinase and p34cdc2/cyclin B during oocyte maturation: p90rsk phosphorylates and inactivates the p34cdc2 inhibitory kinase Myt1
M‐phase entry in eukaryotic cells is driven by activation of MPF, a regulatory factor composed of cyclin B and the protein kinase… Expand
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Highly Cited
1998
Highly Cited
1998
Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.
Activation by growth factors of the Ras-dependent signaling cascade results in the induction of p90 ribosomal S6 kinases (p90(rsk… Expand
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Highly Cited
1997
Highly Cited
1997
The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase‐1β (Rsk‐2) and p70 S6 kinase
The protein kinase C (PKC) inhibitors Ro 318220 and GF 109203X have been used in over 350 published studies to investigate the… Expand
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Highly Cited
1996
Highly Cited
1996
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase
The substrate specificity of protein kinase‐Bα (PKBα, also known as RAC kinase or Akt) was investigated using synthetic peptide… Expand
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Highly Cited
1993
Highly Cited
1993
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
The beta-isoform of glycogen synthase kinase-3 (GSK3 beta) isolated from rabbit skeletal muscle was inactivated 90-95% following… Expand
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Highly Cited
1992
Highly Cited
1992
MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase.
A novel protein kinase, which was only active when phosphorylated by the mitogen‐activated protein kinase (MAP kinase), has been… Expand
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