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Ribosomal Protein S6 Kinase

Known as: Ribosomal Protein S6 Kinases [Chemical/Ingredient], Ribosomal Protein S6 Kinases, S6-H4 Kinase 
A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through… 
National Institutes of Health

Related topics

Related topics

15 relations
Coffin-Lowry syndromeIn BloodPAK2 kinaseProcess of secretion

Broader (2)

PAK2 geneProtein-Serine-Threonine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
A phosphoproteomic analysis of signaling pathways downstream of oncogenic receptor tyrosine kinases identified potential… 
Highly Cited
2005
Highly Cited
2005
The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation.
An increase in the activity of mitogen-activated protein kinase (MAPK) has been correlated with the progression of prostate… 
Review
2005
Review
2005
Restraining PI3K: mTOR signalling goes back to the membrane.
Highly Cited
2004
Highly Cited
2004
Antitumor Efficacy of Intermittent Treatment Schedules with the Rapamycin Derivative RAD001 Correlates with Prolonged Inactivation of Ribosomal Protein S6 Kinase 1 in Peripheral Blood Mononuclear…
The orally bioavailable rapamycin derivative RAD001 (everolimus) targets the mammalian target of rapamycin pathway and possesses… 
Highly Cited
2004
Highly Cited
2004
Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development
ABSTRACT The mammalian target of rapamycin (mTOR) is a key component of a signaling pathway which integrates inputs from… 
Highly Cited
2003
Highly Cited
2003
M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase
AbstractMultinucleated bone-resorbing osteoclasts (Ocl) are cells of hematopoietic origin that play a major role in osteo-porosis… 
Highly Cited
2000
Highly Cited
2000
Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis.
BACKGROUND Studies by comparative genomic hybridization (CGH) have shown that chromosomal region 17q23 is amplified in up to 20… 
Highly Cited
1992
Highly Cited
1992
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
THE macrolide rapamycin induces cell cycle Gl arrest in yeast and in mammalian cells1–3, which suggests that an evolutionarily… 
Highly Cited
1988
Highly Cited
1988
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
Ribosomal protein S6 is a component of the eukaryotic 40S ribosomal subunit that becomes phosphorylated on multiple serine… 
Highly Cited
1987
Highly Cited
1987
Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.
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