Ribosomal Protein S6 Kinase

Known as: Ribosomal Protein S6 Kinases [Chemical/Ingredient], Ribosomal Protein S6 Kinases, S6-H4 Kinase 
A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through… (More)
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
S6 kinases (S6Ks) are mechanistic target of rapamycin substrates that participate in cell growth control. S6Ks phosphorylate… (More)
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Review
2011
Review
2011
In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of… (More)
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Highly Cited
2004
Highly Cited
2004
Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either of the two tumor suppressor genes TSC1 or… (More)
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Highly Cited
2004
Highly Cited
2004
The orally bioavailable rapamycin derivative RAD001 (everolimus) targets the mammalian target of rapamycin pathway and possesses… (More)
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Highly Cited
2002
Highly Cited
2002
Although the cellular functions of TSC2 and its protein product, tuberin, are not known, somatic mutations in the TSC2 tumor… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Studies by comparative genomic hybridization (CGH) have shown that chromosomal region 17q23 is amplified in up to 20… (More)
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Highly Cited
1999
Highly Cited
1999
Regulation of translation of mRNAs coding for specific proteins plays an important role in controlling cell growth… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin… (More)
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Highly Cited
1994
Highly Cited
1994
Phosphatidylinositol 3-kinase (PI 3-kinase) is stimulated by insulin and a variety of growth factors, but its exact role in… (More)
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Highly Cited
1988
Highly Cited
1988
Ribosomal protein S6 is a component of the eukaryotic 40S ribosomal subunit that becomes phosphorylated on multiple serine… (More)
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