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Control of osteoblast function and regulation of bone mass
The skeleton is an efficient 'servo' (feedback-controlled/steady-state) system that continuously integrates signals and responses which sustain its functions of delivering calcium while maintaining… Expand
Therapeutic approaches to bone diseases.
The strength and integrity of our bones depends on maintaining a delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts. As we age or as a result of disease, this… Expand
Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.
- M. Sato, W. Grasser, +5 authors G. Rodan
- The Journal of clinical investigation
- 1 December 1991
Studies of the mode of action of the bisphosphonate alendronate showed that 1 d after the injection of 0.4 mg/kg [3H]alendronate to newborn rats, 72% of the osteoclastic surface, 2% of the bone… Expand
Bisphosphonates: mechanisms of action.
Because of its failure to act when given orally and its rapid hydrolysis when given parenterally, pyrophosphate was used therapeutically only in scintigraphy and against dental calculus. This… Expand
The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection…
OBJECTIVE It has been suggested that subchondral bone remodeling plays a role in the progression of osteoarthritis (OA). To test this hypothesis, we characterized the changes in the rat anterior… Expand
Principles of bone biology
Basic principles - cell biology biochemistry bone re-modelling and mineral homeostasis the hormones of bone other systemic hormones that influence bone metabolism local regulators of bone molecular… Expand
Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase.
- J. Bergstrom, R. Bostedor, P. Masarachia, A. Reszka, G. Rodan
- Medicine, Biology
- Archives of biochemistry and biophysics
Alendronate, a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis. Recent findings suggest that alendronate and other… Expand
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
- J. Fisher, M. Rogers, +7 authors A. Reszka
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 5 January 1999
Nitrogen-containing bisphosphonates were shown to cause macrophage apoptosis by inhibiting enzymes in the biosynthetic pathway leading from mevalonate to cholesterol. This study suggests that, in… Expand
Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.
Interleukin‐6 (IL‐6) is a multifunctional cytokine whose circulating levels are under physiological conditions below detection, but whose production is rapidly and strongly induced by several… Expand
Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties.
This study examines the osteoblastic properties of the established human osteosarcoma cell line Saos-2. Saos-2 cells inoculated into diffusion chambers, which were implanted i.p. into nude mice,… Expand