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PAK2 kinase

Known as: gamma PAK, p21-Activated Kinase 2, PAK-2 Kinase 
National Institutes of Health

Related topics

Related topics

3 relations
PAK2 geneRibosomal Protein S6 Kinase

Broader (1)

p21-Activated Kinases

Papers overview

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2020
2020
CDK12 and PAK2 as novel therapeutic targets for human gastric cancer
Background: Gastric cancer remains the second leading cause of cancer-related death, and the third in mortality due to lack of… 
2019
2019
Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response
Rationale: Secreted and membrane-bound proteins, which account for 1/3 of all proteins, play critical roles in heart health and… 
Highly Cited
2011
Highly Cited
2011
Proteome analysis of erythrocytes lacking AMP-activated protein kinase reveals a role of PAK2 kinase in eryptosis.
Activation of AMP-activated protein kinase (AMPK) upon energy depletion stimulates energy production and limits energy… 
Highly Cited
2009
Highly Cited
2009
MCF-7 breast carcinoma cells do not express caspase-3
Apoptosis, a fundamental process essential for normal tissue homeostasis and development, is closely associated with the… 
Highly Cited
2005
Highly Cited
2005
Stem Cell Depletion Through Epidermal Deletion of Rac1
Mammalian epidermis is maintained by self-renewal of stem cells, but the underlying mechanisms are unknown. Deletion of Rac1, a… 
Review
1998
Review
1998
Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction?
p21-activated kinase 2 (PAK2) is proteolytically cleaved during apoptosis through the action of DEVD-sensitive caspase(s). This… 
Highly Cited
1996
Highly Cited
1996
Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.
The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in… 
Highly Cited
1996
Highly Cited
1996
Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase*
Insulin activates rapidly a complex cascade of lipid and protein kinases leading to stimulation of mitogenic and metabolic events… 
Highly Cited
1996
Highly Cited
1996
Rac “Insert Region” Is a Novel Effector Region That Is Implicated in the Activation of NADPH Oxidase, but Not PAK65*
The small GTPase Rac assembles with the cytosolic p47phox and p67phox and the membrane-associated flavocytochrome b558 to form… 
Highly Cited
1995
Highly Cited
1995
Activation of an S6/H4 Kinase (PAK 65) from Human Placenta by Intramolecular and Intermolecular Autophosphorylation (*)
The S6/H4 kinase purified from human placenta catalyzes phosphorylation of the S6 ribosomal protein, histone H4, and myelin basic… 
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