p21-Activated Kinases

Known as: PAK Kinases, Kinases, PAK, Kinases, p21-Activated 
A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase… (More)
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Review
2006
Review
2006
The pivotal role of kinases in signal transduction and cellular regulation has lent them considerable appeal as pharmacological… (More)
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Review
2003
Review
2003
The p21-activated kinases (PAKs) 1-3 are serine/threonine protein kinases whose activity is stimulated by the binding of active… (More)
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Highly Cited
2000
Highly Cited
2000
The process of macropinocytosis is an essential aspect of normal cell function, contributing to both growth and motile processes… (More)
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Highly Cited
2000
Highly Cited
2000
The p21-activated kinases (PAKs), stimulated by binding with GTP-liganded forms of Cdc42 or Rac, modulate cytoskeletal actin… (More)
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Highly Cited
1999
Highly Cited
1999
p21-activated kinases (PAKs) are implicated in the cytoskeletal changes induced by the Rho family of guanosine triphosphatases… (More)
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Highly Cited
1999
Highly Cited
1999
p21-activated kinases (Pak)/Ste20 kinases are regulated in vitro and in vivo by the small GTP-binding proteins Rac and Cdc42 and… (More)
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Highly Cited
1999
Highly Cited
1999
The p21-activated kinases (Pak) are major targets of the small GTPases Cdc42 and Rac. We, and others, recently identified a… (More)
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Highly Cited
1997
Highly Cited
1997
The mechanisms through which the small GTPases Rac1 and Cdc42 regulate the formation of membrane ruffles, lamellipodia, and… (More)
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Highly Cited
1995
Highly Cited
1995
The Rac guanosine 5'-triphosphate (GTP)-binding proteins regulate oxidant production by phagocytic leukocytes. Two Ste20-related… (More)
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