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Transcriptomics of Post-Stroke Angiogenesis in the Aged Brain
TLDR
The angiogenic response in aged rats was further diminished by the persistent upregulation of “inflammatory” genes and vigorous expression of genes required for the buildup of the fibrotic scar and the remaining brain plasticity of the aged brain.
Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase
TLDR
AMPK is a potent regulator of KCNQ1/KCNE1 and downregulates the epithelial Na+ channel ENaC, an effect mediated by the ubiquitin ligase Nedd4-2.
Rapamycin Sensitive ROS Formation and Na+/H+ Exchanger Activity in Dendritic Cells
TLDR
In DCs rapamycin disrupts LPS induced ROS formation with subsequent inhibition of NHE activity, cell swelling and TNF-α release.
Effect of Thymoquinone on Cytosolic pH and Na+/H+ Exchanger Activity in Mouse Dendritic Cells
TLDR
Thymoquinone blunts LPS induced NHE activity, cell swelling, oxidative burst, cytokine release and migration of bone marrow derived murine dendritic cells, and may contribute to the antiinflammatory action of thymOquinone.
p38 MAPK Activation and Function following Osmotic Shock of Erythrocytes
TLDR
P38 kinase is expressed in erythrocytes and participates in the machinery triggering eryptosis following hyperosmotic shock, which is phosphorylated upon osmotic shock.
Stimulation of Suicidal Erythrocyte Death by Benzethonium
TLDR
A novel effect of benzethonium is disclosed, i.e. triggering of suicidal death of erythrocytes, which significantly enhanced lactic acid formation but not ceramide abundance.
Proteome analysis of erythrocytes lacking AMP-activated protein kinase reveals a role of PAK2 kinase in eryptosis.
TLDR
It is shown that specific inactivation of PAK2 with the inhibitor IPA3 in human and murine ampk(+/+) erythrocytes increases the binding of annexin V and augments the stimulating effect of glucose deprivation on Annexin V-binding, showing that AMPK and PAK 2 exert similar phenotypes upon inactivation in ery Throcytes.
Vitamin D-Rich Diet in Mice Modulates Erythrocyte Survival
TLDR
The present observations point to a subtle effect of exogenous vitamin D supplementation on erythrocyte survival, which is likely to be associated with anemia.
Hexavalent chromium-induced erythrocyte membrane phospholipid asymmetry
TLDR
The present observations disclose a novel effect of chromium (VI), i.e. Ca2+ entry and cytosolic ATP depletion in erythrocytes, effects resulting in ERYptosis with cell shrinkage and cell membrane scrambling.
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