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PAK2 gene

Known as: PAK65, p21 protein (Cdc42/Rac)-activated kinase 2, p21 PROTEIN-ACTIVATED KINASE 2 
National Institutes of Health

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Related topics

3 relations
PAK1 genePAK2 kinase

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Ribosomal Protein S6 Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
CCHE1 accelerated the initiation of oral squamous cell carcinoma through enhancing PAK2 expression by sponging miR-922.
BACKGROUND Oral squamous cell carcinoma (OSCC) is a normal form of mouth cancer, comprising the majority of oral cancers. A large… 
2014
2014
A Multiparametric Serum Marker Panel as a Complementary Test to Mammography for the Diagnosis of Node-Negative Early-Stage Breast Cancer and DCIS in Young Women
Background: The sensitivity of mammography for the detection of small lesions, including node-negative early-stage (T1N0) primary… 
2013
2013
HIV-1 Nef mediates Pak phosphorylation of Mek1 serine298 and elicits an active phospho-state of Pak2.
The HIV-1 Nef protein brings about increased T cell activity and viral titers through mechanisms that are poorly understood. Nef… 
2012
2012
Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix
BackgroundHIV-1 Nef is a multifunctional protein required for full pathogenicity of the virus. As Nef has no known enzymatic… 
2010
2010
Mechanistic Studies of the Autoactivation of PAK2
Protein kinase activation, via autophosphorylation of the activation loop, is a common regulatory mechanism in phosphorylation… 
Highly Cited
2008
Highly Cited
2008
Pak1 and Pak2 Mediate Tumor Cell Invasion through Distinct Signaling Mechanisms
ABSTRACT Pak kinases are thought to play critical roles in cell migration and invasion. Here, we analyze the roles of Pak1 and… 
2008
2008
Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.
The tyrosine kinase c-Abl is implicated in a variety of cellular processes that are tightly regulated by c-Abl kinase activity… 
2008
2008
The role and regulation of PAK isoforms in cancer cell migration
p21-activated kinases (PAKs) are downstream targets of many Rho GTPases. They have been implicated as regulators of cell… 
2003
2003
Evaluation of the catalytic mechanism of the p21-activated protein kinase PAK2.
The p21-activated kinases (PAKs) play important roles in diverse cellular processes. In the present study, we provide an in-depth… 
2003
2003
The Mechanism of p21-activated Kinase 2 Autoactivation*
The p21-activated kinases (PAKs) play an important role in diverse cellular processes. PAK2 is activated by autophosphorylation… 
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