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HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T Cells
Binding of the HIV envelope to the chemokine coreceptors triggers membrane fusion and signal transduction. The fusion process has been well characterized, yet the role of coreceptor signaling remainsExpand
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Selective Transcription and Modulation of Resting T Cell Activity by Preintegrated HIV DNA
The quiescent nature of most peripheral T cells poses an effective limitation to human immunodeficiency virus (HIV) replication and, in particular, to viral integration into the host chromatin. TwoExpand
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Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.
Although human immunodeficiency virus (HIV) Nef is essential for the induction of AIDS, its biochemical function has remained an enigma. In this study, HIV Nef protein is shown to associate with aExpand
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HIV-1 Nef increases T cell activation in a stimulus-dependent manner.
  • J. Schrager, J. Marsh
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 6 July 1999
Lentiviral Nef increases viral replication in vivo, plays a direct role in pathogenesis, and increases viral particle infectivity. We now find that HIV Nef also increases the activation of T cells, aExpand
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Early Transcription from Nonintegrated DNA in Human Immunodeficiency Virus Infection
  • Y. Wu, J. Marsh
  • Biology, Medicine
  • Journal of Virology
  • 1 October 2003
ABSTRACT Replication of human immunodeficiency virus (HIV) involves obligatory sequential processes. Following viral entry and reverse transcription, the newly synthesized viral DNA integrates intoExpand
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Human macrophages support persistent transcription from unintegrated HIV-1 DNA.
Retroviruses require integration of their RNA genomes for both stability and productive viral replication. In HIV infection of non-dividing, resting CD4 T cells, where integration is greatly impeded,Expand
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Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.
Human immunodeficiency virus type 1 (HIV-1) Nef is a myristylated protein with a relative molecular mass of 27 kDa, is localized to the cytoplasmic surfaces of cellular membranes, and has beenExpand
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Rev-dependent indicator T cell line.
Measuring virion infectivity is critical for studying and monitoring the process of HIV-1 infection. The easiest and the most common method utilizes reporter cell lines based on the HIV LTR promoter.Expand
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HIV-1 Nef activity in murine T cells. CD4 modulation and positive enhancement.
Immediately after infection of the targeted cell by HIV-1, proviral gene expression is limited to the three regulatory proteins, Tat, Rev, and Nef, with the nef transcript representing nearly 80% ofExpand
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Human Immunodeficiency Virus Type 1-Derived Lentivirus Vectors Pseudotyped with Envelope Glycoproteins Derived from Ross River Virus and Semliki Forest Virus
ABSTRACT Ross River virus (RRV) and Semliki Forest virus (SFV) are two alphaviruses that have a high degree of amino acid homology, as well as a very broad host range. We show here that envelopeExpand
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