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Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
By focusing on activated cell circuitry, the approach outlined here provides insight into cancer biology not available at the chromosomal and transcriptional levels and can be applied broadly across all human cancers. Expand
SIRT 3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Sirtuins are NAD-dependent protein deacetylases. They mediate adaptive responses to a variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is localized in theExpand
Activity and Connectivity of Brain Mood Regulating Circuit in Depression: A Functional Magnetic Resonance Study
The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic areas is consistent with the hypothesis that decreased cortical regulation of limbics activation in response to negative stimuli may be present in depression. Expand
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
It is shown that S6K1 directly phosphorylates IRS-1 Ser-1101 in vitro in the C-terminal domain of the protein and that mutation of this site largely blocks the ability of amino acids to suppress IRS- 1 tyrosine and Akt phosphorylation. Expand
MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice
This is the first demonstration that cellular gene expression patterns in influenza virus-infected mice may be attributed in part to microRNA regulation and that such regulation may be a contributing factor to the extreme virulence of the r1918. Expand
Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
A phosphoproteomic approach to identify targets of three core signaling pathways—all of which involve activation of AGC family kinases—downstream of oncogenic RTKs is developed, revealing previously unidentified Akt–RSK–S6 kinase substrates that merit further consideration as targets for combination therapy with RTKIs. Expand
Massive Sorghum Collection Genotyped with SSR Markers to Enhance Use of Global Genetic Resources
A large diversity survey in sorghum with 3367 accessions and 41 reference nuclear SSR markers is presented and a core reference set is proposed in order to facilitate integrated phenotyping experiments towards refined functional understanding of Sorghum diversity. Expand
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
It is demonstrated that adenovirus‐mediated overexpression of SIRT1 in the liver of diet‐induced insulin‐resistant low‐density lipoprotein receptor‐deficient mice and of genetically obese ob/ob mice attenuates hepatic steatosis and ameliorates systemic insulin resistance and restores glucose homeostasis. Expand
A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in rats
The results suggest that mdivi-1 exerts neuroprotective effects against nerve injury after cerebral ischemia/reperfusion, and the underlying mechanism may be through the prevention of Cytochrome C release and suppression of the mitochondrial apoptosis pathway. Expand
IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
IL-15 acts not only as a crucial growth factor but also as an antigen-independent activator of effector functions for CD8+ memory T cells, showing that IL-15 and anti-CD3 stimulation induced remarkably similar gene expression and effector function. Expand