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- Publications
- Influence
Role of AMP-activated protein kinase in mechanism of metformin action.
- G. Zhou, R. Myers, +11 authors D. Moller
- Chemistry, Medicine
- The Journal of clinical investigation
- 15 October 2001
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and… Expand
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.
- J. Brüning, M. Michael, +5 authors C. Kahn
- Biology, Medicine
- Molecular cell
- 1 November 1998
Skeletal muscle insulin resistance is among the earliest detectable defects in humans with type 2 diabetes mellitus. To determine the contribution of muscle insulin resistance to the metabolic… Expand
Exercise, glucose transport, and insulin sensitivity.
- L. Goodyear, B. Kahn
- Biology, Medicine
- Annual review of medicine
- 1998
Physical exercise can be an important adjunct in the treatment of both non-insulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus. Over the past several years, considerable… Expand
Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle*
- E. Taylor, D. An, +8 authors L. Goodyear
- Biology, Medicine
- Journal of Biological Chemistry
- 11 April 2008
The Akt substrate of 160 kDa (AS160) is phosphorylated on Akt substrate (PAS) motifs in response to insulin and contraction in skeletal muscle, regulating glucose uptake. Here we discovered a… Expand
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.
- K. Stanford, R. J. Middelbeek, +8 authors L. Goodyear
- Biology, Medicine
- The Journal of clinical investigation
- 2 January 2013
Brown adipose tissue (BAT) is known to function in the dissipation of chemical energy in response to cold or excess feeding, and also has the capacity to modulate energy balance. To test the… Expand
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
- O. Palacios, J. J. Carmona, +5 authors Q. Tong
- Biology, Medicine
- Aging
- 15 August 2009
SIRT3 is a member of the sirtuin family of NAD+-dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active… Expand
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
- M. Griffin, M. Marcucci, +7 authors G. Shulman
- Biology, Medicine
- Diabetes
- 1 June 1999
To examine the mechanism by which free fatty acids (FFAs) induce insulin resistance in vivo, awake chronically catheterized rats underwent a hyperinsulinemic-euglycemic clamp with or without a 5-h… Expand
Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport
- T. Hayashi, M. Hirshman, E. Kurth, W. Winder, L. Goodyear
- Biology, Medicine
- Diabetes
- 1 August 1998
The intracellular signaling proteins that lead to exercise-stimulated glucose transport in skeletal muscle have not been identified, although it is clear that there are separate signaling mechanisms… Expand
AS160 Regulates Insulin- and Contraction-stimulated Glucose Uptake in Mouse Skeletal Muscle*
- H. F. Kramer, C. A. Witczak, E. Taylor, N. Fujii, M. Hirshman, L. Goodyear
- Biology, Medicine
- Journal of Biological Chemistry
- 20 October 2006
Insulin and contraction are potent stimulators of GLUT4 translocation and increase skeletal muscle glucose uptake. We recently identified the Rab GTPase-activating protein (GAP) AS160 as a putative… Expand
Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle
- H. F. Kramer, C. A. Witczak, +6 authors L. Goodyear
- Chemistry, Medicine
- Diabetes
- 1 July 2006
Insulin and contraction increase GLUT4 translocation in skeletal muscle via distinct signaling mechanisms. Akt substrate of 160 kDa (AS160) mediates insulin-stimulated GLUT4 translocation in L6… Expand