Post-translational modification of p53 in tumorigenesis
A thorough understanding of p53 will be extremely useful in the development of new strategies for treating and preventing cancer, including restoration of p 53 function and selective killing of tumours with mutant TP53.
Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.
Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases*
- Zhanguo Gao, A. Zuberi, M. Quon, Z. Dong, Jianping Ye
- Biology, ChemistryJournal of Biological Chemistry
- 1 July 2003
Aspirin may enhance insulin sensitivity by protecting IRS proteins from serine phosphorylation catalyzed by multiple kinases, as assessed by phospho-specific antibodies.
Mitogen-Activated Protein Kinase Activation in UV-Induced Signal Transduction
Accumulating evidence suggests that the cellular responses produced by UV irradiation are likely to be wavelength-dependent, and this review focuses on the mechanistic data supporting a role for MAPKs in UV-stimulated skin carcinogenesis.
ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation*
It is found that in a mouse JB6 epidermal cell line, ERKs and p38 kinase form a complex with p53 following UVB radiation, providing evidence that UVB-induced phosphorylation of p53 at serine 15 is mediated directly by ERKS and p 38 kinase.
(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.
Results strongly suggested that EGCG could prevent the antiapoptotic effect of GRP78, which usually suppresses the caspase-mediated cell death pathways in drug-treated cancer cells, contributing to the development of drug resistance.
Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem Cells
Phosphorylation of Sox2 cooperates in the reprogramming of mouse embryonic fibroblasts by enabling more efficient induction of iPSCs and provides a direct link between phosphorylation events and somatic cell reprograming.
Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.
It is reported that red wine extract or the red wine flavonoid quercetin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transformation of JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells.
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.
- Z. Dong, M. Birrer, R. Watts, L. Matrisian, N. Colburn
- BiologyProceedings of the National Academy of Sciences…
- 18 January 1994
Results indicate that AP-1 activity is required for TPA- or EGF-induced transformation in JB6 P+ cells, and demonstrates that a specific block in induced AP- 1 activity inhibits tumor promoter- induced transformation.
Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.
It is found that T-cell-originated protein kinase (TOPK), a member of the MAPKK protein family, is highly expressed in human colorectal cancer tissues and cell lines and plays an important role in the transformation of coloreCTal cancer.