Regulatory Sequences, Nucleic Acid
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Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the… Expand Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or… Expand We developed the Genomic Regions Enrichment of Annotations Tool (GREAT) to analyze the functional significance of cis-regulatory… Expand Through alternative processing of pre-messenger RNAs, individual mammalian genes often produce multiple mRNA and protein isoforms… Expand DNA methylation is essential for normal development and has been implicated in many pathologies including cancer. Our knowledge… Expand Lipid homeostasis in vertebrate cells is regulated by a family of membrane-bound transcription factors designated sterol… Expand As targets for the immunosuppressive drugs cyclosporin A and FK506, transcription factors of the NFAT (nuclear factor of… Expand Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal… Expand Abstract: Mood, emotion, cognition, and motor functions as well as circadian and neuroendocrine rhythms, including food intake… Expand The iron storage protein, ferritin, plays a key role in iron metabolism. Its ability to sequester the element gives ferritin the… Expand