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Locus Control Region

Known as: Region, Locus Control, Regions, Locus Control, Control Region, Locus 
A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Regulatory Sequences, Nucleic Acid
aspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Cooperativeness of the higher chromatin structure of the beta-globin locus revealed by the deletion mutations of DNase I hypersensitive site 3 of the LCR.
2000
2000
Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region.
Mammalian beta-globin loci are composed of multiple orthologous genes whose expression is erythroid specific and developmentally… 
2000
2000
Control of Organ-specific Demethylation by an Element of the T-cell Receptor-α Locus Control Region*
DNA methylation is important for mammalian development and the control of gene expression. Recent data suggest that DNA… 
Highly Cited
1999
Highly Cited
1999
Hypersensitive Site 2 Specifies a Unique Function within the Human β-Globin Locus Control Region To Stimulate Globin Gene Transcription
ABSTRACT The human β-globin locus control region (LCR) harbors both strong chromatin opening and enhancer activity when assayed… 
Highly Cited
1998
Highly Cited
1998
The Immunoglobulin Heavy Chain Locus Control Region Increases Histone Acetylation along Linked c-myc Genes
ABSTRACT In chromosome translocations characteristic of Burkitt lymphomas (BL) and murine plasmacytomas, c-myc genes become… 
Highly Cited
1996
Highly Cited
1996
Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome…
To analyze the function of the 5' DNase I hypersensitive sites (HSs) of the locus control region (LCR) on beta-like globin gene… 
1995
1995
A central role for a single c-Myb binding site in a thymic locus control region
Locus control regions (LCRs) are powerful assemblies of cis elements that organize the actions of cell-type-specific trans-acting… 
Review
1994
Review
1994
Chromatin domains as potential units of eukaryotic gene function.
Highly Cited
1992
Highly Cited
1992
A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice
The beta-globin gene complex is regulated by an upstream locus control region (LCR) which is responsible for high-level, position… 
Highly Cited
1991
Highly Cited
1991
Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice.
The human beta-globin locus control region (LCR) is essential for high-level expression of human epsilon-, gamma-, and beta… 
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