Locus Control Region

Known as: Region, Locus Control, Regions, Locus Control, Control Region, Locus 
A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Chromatin loops juxtapose distal enhancers with active promoters, but their molecular architecture and relationship with… (More)
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Highly Cited
2007
Highly Cited
2007
Long-range interactions between distant regulatory elements, such as enhancers, and their target genes underlie the specificity… (More)
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Highly Cited
2006
Highly Cited
2006
We have examined the relationship between nuclear localization and transcriptional activity of the endogenous murine beta-globin… (More)
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Highly Cited
2005
Highly Cited
2005
Recent evidence suggests that long-range enhancers and gene promoters are in close proximity, which might reflect the formation… (More)
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Highly Cited
2004
Highly Cited
2004
We recently identified a 3' region of the rad50 gene possessing strong enhancer activity as well as activity consistent with… (More)
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Highly Cited
2002
Highly Cited
2002
Eukaryotic transcription can be regulated over tens or even hundreds of kilobases. We show that such long-range gene regulation… (More)
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Review
2002
Review
2002
Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to… (More)
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Highly Cited
2001
Highly Cited
2001
Histone acetylation precedes activation of many genes. However, the establishment and consequences of long-range acetylation… (More)
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Highly Cited
2000
Highly Cited
2000
We have generated mice with a targeted deletion of the beta-globin locus control region (LCR). Mice homozygous for the deletion… (More)
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Highly Cited
1996
Highly Cited
1996
Human CD2 locus control region (LCR) sequences are shown here to be essential for establishing an open chromatin configuration… (More)
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