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Locus Control Region
Known as:
Region, Locus Control
, Regions, Locus Control
, Control Region, Locus
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A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC…
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National Institutes of Health
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Related topics
Related topics
3 relations
Broader (1)
Regulatory Sequences, Nucleic Acid
aspects of radiation effects
physiological aspects
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
The Human β-Globin Locus Control Region Can Silence as Well as Activate Gene Expression
Yong-qing Feng
,
Renaud F. Warin
,
+7 authors
E. Bouhassira
Molecular and Cellular Biology
2005
Corpus ID: 30904646
ABSTRACT Using recombinase-mediated cassette exchange to test multiple transgenes at the same site of integration, we demonstrate…
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Review
2004
Review
2004
Activation of the human GH gene cluster: roles for targeted chromatin modification
Y. Ho
,
S. Liebhaber
,
N. Cooke
Trends in endocrinology and metabolism
2004
Corpus ID: 34578751
Review
2003
Review
2003
Genomic domains and regulatory elements operating at the domain level.
S. Razin
,
C. Farrell
,
F. Recillas-Targa
International Review of Cytology
2003
Corpus ID: 24868007
2000
2000
Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region.
M. Bender
,
M. Mehaffey
,
+4 authors
S. Fiering
Blood
2000
Corpus ID: 36315212
Mammalian beta-globin loci are composed of multiple orthologous genes whose expression is erythroid specific and developmentally…
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2000
2000
Control of Organ-specific Demethylation by an Element of the T-cell Receptor-α Locus Control Region*
B. Santoso
,
B. D. Ortiz
,
A. Winoto
Journal of Biological Chemistry
2000
Corpus ID: 35034207
DNA methylation is important for mammalian development and the control of gene expression. Recent data suggest that DNA…
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Highly Cited
1996
Highly Cited
1996
Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome…
Kenneth R. Peterson
,
Christopher H. Clegg
,
P. Navas
,
Elizabeth J. Norton
,
Tyler G. Kimbrough
,
George Stamatoyannopoulos
Proceedings of the National Academy of Sciences…
1996
Corpus ID: 23572613
To analyze the function of the 5' DNase I hypersensitive sites (HSs) of the locus control region (LCR) on beta-like globin gene…
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1995
1995
A central role for a single c-Myb binding site in a thymic locus control region
K. Ess
,
T. Whitaker
,
G. Cost
,
D. Witte
,
J. Hutton
,
B. Aronow
Molecular and Cellular Biology
1995
Corpus ID: 40716995
Locus control regions (LCRs) are powerful assemblies of cis elements that organize the actions of cell-type-specific trans-acting…
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Review
1994
Review
1994
Chromatin domains as potential units of eukaryotic gene function.
N. Dillon
,
F. Grosveld
Current Opinion in Genetics and Development
1994
Corpus ID: 22061990
Highly Cited
1992
Highly Cited
1992
A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice
B. J. Morley
,
C. Abbott
,
J. Sharpe
,
J. Lida
,
P. Chan-Thomas
,
W. Wood
Molecular and Cellular Biology
1992
Corpus ID: 8891680
The beta-globin gene complex is regulated by an upstream locus control region (LCR) which is responsible for high-level, position…
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Highly Cited
1991
Highly Cited
1991
Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice.
John J. Caterina
,
Thomas M. Ryan
,
+4 authors
T. Townes
Proceedings of the National Academy of Sciences…
1991
Corpus ID: 23257942
The human beta-globin locus control region (LCR) is essential for high-level expression of human epsilon-, gamma-, and beta…
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