Locus Control Region

Known as: Region, Locus Control, Regions, Locus Control, Control Region, Locus 
A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC… (More)
National Institutes of Health

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Broader (1)

Regulatory Sequences, Nucleic Acid
aspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2012
Highly Cited
2012
Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping Factor
Chromatin loops juxtapose distal enhancers with active promoters, but their molecular architecture and relationship with… (More)
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Highly Cited
2007
Highly Cited
2007
A positive role for NLI/Ldb1 in long-range beta-globin locus control region function.
Long-range interactions between distant regulatory elements, such as enhancers, and their target genes underlie the specificity… (More)
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Highly Cited
2006
Highly Cited
2006
The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation.
We have examined the relationship between nuclear localization and transcriptional activity of the endogenous murine beta-globin… (More)
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Highly Cited
2005
Highly Cited
2005
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.
Recent evidence suggests that long-range enhancers and gene promoters are in close proximity, which might reflect the formation… (More)
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Highly Cited
2004
Highly Cited
2004
Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region.
We recently identified a 3' region of the rad50 gene possessing strong enhancer activity as well as activity consistent with… (More)
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Highly Cited
2002
Highly Cited
2002
Looping and interaction between hypersensitive sites in the active beta-globin locus.
Eukaryotic transcription can be regulated over tens or even hundreds of kilobases. We show that such long-range gene regulation… (More)
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Review
2002
Review
2002
Locus control regions.
Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to… (More)
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Highly Cited
2001
Highly Cited
2001
Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter.
Histone acetylation precedes activation of many genes. However, the establishment and consequences of long-range acetylation… (More)
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Highly Cited
2000
Highly Cited
2000
Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region.
We have generated mice with a targeted deletion of the beta-globin locus control region (LCR). Mice homozygous for the deletion… (More)
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Highly Cited
1996
Highly Cited
1996
Locus control region function and heterochromatin-induced position effect variegation.
Human CD2 locus control region (LCR) sequences are shown here to be essential for establishing an open chromatin configuration… (More)
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