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Locus Control Region

Known as: Region, Locus Control, Regions, Locus Control, Control Region, Locus 
A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Regulatory Sequences, Nucleic Acid
aspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
The Human β-Globin Locus Control Region Can Silence as Well as Activate Gene Expression
ABSTRACT Using recombinase-mediated cassette exchange to test multiple transgenes at the same site of integration, we demonstrate… 
2003
2003
Insulators to improve expression of a 3(')IgH LCR-driven reporter gene in transgenic mouse models.
Review
2003
Review
2003
Genomic domains and regulatory elements operating at the domain level.
Highly Cited
2001
Highly Cited
2001
Intergenic Transcription in the Human β-Globin Gene Cluster
ABSTRACT Our previous studies on nascent transcription across the human β-globin gene cluster revealed the presence of intergenic… 
2000
2000
Control of Organ-specific Demethylation by an Element of the T-cell Receptor-α Locus Control Region*
DNA methylation is important for mammalian development and the control of gene expression. Recent data suggest that DNA… 
2000
2000
Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region.
Mammalian beta-globin loci are composed of multiple orthologous genes whose expression is erythroid specific and developmentally… 
1999
1999
Structural analysis and mapping of DNase I hypersensitivity of HS5 of the beta-globin locus control region.
The beta-globin locus control region (LCR) is a cis regulatory element that is located in the 5' part of the locus and confers… 
Review
1997
Review
1997
Silencers and locus control regions: opposite sides of the same coin.
1996
1996
Sequences Within and Flanking Hypersensitive Sites 3 and 2 of the β-Globin Locus Control Region Required for Synergistic Versus Additive Interaction With the ε-globin Gene Promoter
The locus control region is required for high-level, position-independent expression of mammalian beta-globin genes. It is marked… 
1995
1995
A central role for a single c-Myb binding site in a thymic locus control region
Locus control regions (LCRs) are powerful assemblies of cis elements that organize the actions of cell-type-specific trans-acting… 
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