• Publications
  • Influence
Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains.
Recent advances enabled by the Hi-C technique have unraveled many principles of chromosomal folding that were subsequently linked to disease and gene regulation. In particular, Hi-C revealed thatExpand
  • 218
  • 21
  • PDF
Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition
Chromatin is reprogrammed after fertilization to produce a totipotent zygote with the potential to generate a new organism. The maternal genome inherited from the oocyte and the paternal genomeExpand
  • 342
  • 18
The nuclear matrix and chromosomal DNA loops: is their any correlation between partitioning of the genome into loops and functional domains?
  • S. Razin
  • Biology, Medicine
  • Cellular & molecular biology letters
  • 2001
In this paper we are presenting a critical analysis of the results of experiments aimed to elucidate the principles of the eukaryotic genome structural-functional organization. Although the DNA loopsExpand
  • 58
  • 14
  • PDF
Specificity and functional significance of DNA interaction with the nuclear matrix: new approaches to clarify the old questions.
In this chapter the specificity of chromosomal DNA partitioning into topological loops is discussed. Different experimental approaches used for the analysis of the above problem are criticallyExpand
  • 92
  • 7
Visualization of individual DNA loops and a map of loop domains in the human dystrophin gene.
The organization of the human dystrophin gene into loop domains has been studied using two different experimental approaches: excision of DNA loops mediated by nuclear matrix-bound topoisomerase IIExpand
  • 64
  • 6
  • PDF
Mechanisms of heat shock response in mammals
Heat shock (HS) is one of the best-studied exogenous cellular stresses. The cellular response to HS utilizes ancient molecular networks that are based primarily on the action of stress-induced heatExpand
  • 90
  • 5
Cys2His2 zinc finger protein family: Classification, functions, and major members
Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in eukaryotic transcription factors. Zinc fingers are short protein motifs composed of two or three β-layers and one α-helix. TwoExpand
  • 96
  • 4
Large-scale Fragmentation of Mammalian DNA in the Course of Apoptosis Proceeds via Excision of Chromosomal DNA Loops and Their Oligomers (*)
It has been shown recently that apoptotic degradation of genomic DNA in mammalian cells starts by excision of large DNA fragments ranging in size from 50 kilobases to more then 300 kilobases.Expand
  • 124
  • 4
Long-range Fragmentation of the Eukaryotic Genome by Exogenous and Endogenous Nucleases Proceeds in a Specific Fashion via Preferential DNA Cleavage at Matrix Attachment Sites (*)
Small cell lung cancer cells (OC-NYH-VM) were permeabilized and treated with different nucleases. The long-range distribution of DNA cleavage sites in the amplified c-myc gene locus was then analyzedExpand
  • 52
  • 4
  • PDF
Communication of genome regulatory elements in a folded chromosome
The most popular model of gene activation by remote enhancers postulates that the enhancers interact directly with target promoters via the looping of intervening DNA fragments. This interaction isExpand
  • 39
  • 3