• Publications
  • Influence
The Regulatory Genome: Gene Regulatory Networks In Development And Evolution
The "Regulatory Genome" for Animal Development and Gene Regulatory Networks: The Roots of Causality and Diversity in Animal Evolution are presented. Expand
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Two small RNAs regulate the timing of Caenorhabditis elegans development and may control late temporal transitions during development across animal phylogeny. Expand
Direct multiplexed measurement of gene expression with color-coded probe pairs
Comparisons of transcript levels for 21 genes across seven samples measured by the nCounter system and SYBR Green real-time PCR demonstrated similar patterns of gene expression at all transcript levels, demonstrating that the n counter system is more sensitive than microarrays and similar in sensitivity to real- time PCR. Expand
A Genomic Regulatory Network for Development
A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here and reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time. Expand
Global regulatory logic for specification of an embryonic cell lineage
The gene regulatory network (GRN) that directs the specification of the skeletogenic micromere lineage of the sea urchin embryo is presented and precisely predicts gene expression responses and provides a coherent explanation of the biology of specification. Expand
The hardwiring of development: organization and function of genomic regulatory systems.
The key to understanding how genomic regulatory networks are organized, and how they work, lies in experimental analysis of cis-regulatory systems at all levels of the regulatory network. Expand
Gene Regulatory Networks and the Evolution of Animal Body Plans
This work identifies a class of GRN component, the kernels, of the network, which, because of their developmental role and their particular internal structure, are most impervious to change. Expand
Genomic Regulatory Systems: Development and Evolution
Genomic Regulatory Systems: Development and Evolution hierarchisch: generelle Dinge wie anterior/posterior Ausrichtung zuerst, dann mehr und mehr Details "heart of pattern formation: regionalExpand
Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin gene.
A quantitative computational model was constructed that explicitly reveals the logical interrelations hard-wired into the DNA of a sea urchin control element that directs the expression of a gene in the endoderm during development. Expand