The multifaceted mismatch-repair system
- J. Jiricny
- BiologyNature reviews. Molecular cell biology
- 1 May 2006
This article reviews the current understanding of this multifaceted DNA-repair system in human cells and investigates how MMR status affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes.
Transcriptome Profile of Human Colorectal Adenomas
- Jacob Sabates-Bellver, Laurens G. van der Flier, G. Marra
- Biology, MedicineMolecular Cancer Research
- 1 December 2007
Significant differences emerged not only between the expression profiles of normal and adenomatous tissues but also between those of small and large adenomas, and KIAA1199 was identified as a novel target of the Wnt signaling pathway and a putative marker of colorectal adenOMatous transformation.
Modification of the human thymine‐DNA glycosylase by ubiquitin‐like proteins facilitates enzymatic turnover
- U. Hardeland, R. Steinacher, J. Jiricny, P. Schär
- Biology, ChemistryEMBO Journal
- 15 March 2002
It is shown that TDG interacts with and is covalently modified by the ubiquitin‐like proteins SUMO‐1 andsumO‐2/3, and SUMO conjugation dramatically reduces the DNA substrate and AP site binding affinity of TDG, and this is associated with a significant increase in enzymatic turnover in reactions with a G·U substrate and the loss of G·T processing activity.
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.
- Lovorka Stojic, N. Mojas, J. Jiricny
- Biology, ChemistryGenes & Development
- 1 June 2004
It is shown that MNNG treatment induced a cell cycle arrest that was absolutely dependent on functional MMR, and the response of human MMR-proficient and MMR-deficient cells to low concentrations of the prototypic methylating agent N-methyl-N'-nitro-N-nitrosoguanidine.
hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci.
- H. Kleczkowska, G. Marra, T. Lettieri, J. Jiricny
- BiologyGenes & Development
- 15 March 2001
It is postulate that PCNA plays a role in repair initiation by guiding the mismatch repair proteins to free termini in the newly replicated DNA strands.
The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
- B. Hendrich, U. Hardeland, H. Ng, J. Jiricny, A. Bird
- Biology, ChemistryNature
- 16 September 1999
MBD4, an unrelated mammalian protein that contains a methyl-CpG binding domain, can also efficiently remove thymine or uracil from a mismatches CpG site in vitro and the combined specificities of binding and catalysis indicate that this enzyme may function to minimize mutation at methyl-GpG.
Mismatch repair and DNA damage signalling.
- Lovorka Stojic, R. Brun, J. Jiricny
- BiologyDNA Repair
- 1 August 2004
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability
- D. Cortázar, C. Kunz, P. Schär
- 17 February 2011
It is shown that TDG contributes to the maintenance of active and bivalent chromatin throughout cell differentiation, facilitating a proper assembly of chromatin-modifying complexes and initiating base excision repair to counter aberrant de novo methylation, and has evolved to provide epigenetic stability in lineage committed cells.
Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents
- K. Kratz, Barbara Schöpf, J. Jiricny
- 9 July 2010
Postreplicative mismatch repair.
- J. Jiricny
- BiologyCold Spring Harbor Perspectives in Biology
- 1 April 2013
The progress in the understanding of the mechanism of replication error repair made during the past decade is reviewed.