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In the 10 years since our previous International Union of Basic and Clinical Pharmacology report on the nomenclature and… Expand The adenosine class of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) mediates the… Expand Adenosine is a key endogenous molecule that regulates tissue function by activating four G-protein-coupled adenosine receptors… Expand Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the world. There is growing evidence that… Expand Four adenosine receptors have been cloned and characterized from several mammalian species. The receptors are named adenosine A(1… Expand Adenosine is a modulator that has a pervasive and generally inhibitory effect on neuronal activity. Tonic activation of adenosine… Expand Caffeine is the most widely consumed central-nervous-system stimulant. Three main mechanisms of action of caffeine on the central… Expand BackgroundPreconditioning (5 minutes of ischemia followed by 10 minutes of recovery) renders the heart very resistant to… Expand Cell surface adenosine receptors mediate either stimulation or inhibition of adenylate cyclase activity [ATP pyrophosphate-lyase… Expand Abstract— In cell cultures of glial character derived from perinatal mouse brain adenosine elicits two effects. (a) At… Expand