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Physiology and pathophysiology of purinergic neurotransmission.
  • G. Burnstock
  • Medicine, Biology
  • Physiological reviews
  • 1 April 2007
This review is focused on purinergic neurotransmission, i.e., ATP released from nerves as a transmitter or cotransmitter to act as an extracellular signaling molecule on both pre- and postjunctionalExpand
  • 1,316
  • 137
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of Pharmacology subcommittee. More receptorExpand
  • 1,075
  • 101
Purine and pyrimidine receptors
  • G. Burnstock
  • Medicine, Biology
  • Cellular and Molecular Life Sciences
  • 19 March 2007
Abstract.Adenosine 5′-triphosphate (ATP), in addition to its intracellular roles, acts as an extracellular signalling molecule via a rich array of receptors, which have been cloned and characterised.Expand
  • 786
  • 71
Nomenclature and classification of purinoceptors.
“Receptors recognize a distinct chemical entity and translate information from that entity into a form that the cell can read to alter its state” (Kenakin et al., 1992). Even though the receptors areExpand
  • 1,225
  • 54
A P2X purinoceptor expressed by a subset of sensory neurons
ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation when released from damaged tissue1-10. Here we report the molecular cloning and characterization of a newExpand
  • 898
  • 54
Purinergic signalling in the nervous system: an overview
Purinergic receptors, represented by several families, are arguably the most abundant receptors in living organisms and appeared early in evolution. After slow acceptance, purinergic signalling inExpand
  • 668
  • 54
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X 3-deficient mice
Extracellular ATP is implicated in numerous sensory processes ranging from the response to pain to the regulation of motility in visceral organs. The ATP receptor P2X3 is selectively expressed onExpand
  • 928
  • 48
Purinergic signalling in neuron–glia interactions
Activity-dependent release of ATP from synapses, axons and glia activates purinergic membrane receptors that modulate intracellular calcium and cyclic AMP. This enables glia to detect neural activityExpand
  • 701
  • 46
International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.
ATP acts as a humoral mediator to control cell function extracellularly. The receptors that mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the transmitter-gated,Expand
  • 608
  • 45
Cellular distribution and functions of P2 receptor subtypes in different systems.
This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body. Each sectionExpand
  • 689
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