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Receptors for purines and pyrimidines.
TLDR
In this review particular emphasis is placed on the discrepancy between the concentrations ofadenosine, ADP, and ATP in the purine receptors of UDP and UTP. Expand
Physiology and pathophysiology of purinergic neurotransmission.
  • G. Burnstock
  • Biology, Medicine
  • Physiological reviews
  • 1 April 2007
This review is focused on purinergic neurotransmission, i.e., ATP released from nerves as a transmitter or cotransmitter to act as an extracellular signaling molecule on both pre- and postjunctionalExpand
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of Pharmacology subcommittee. More receptorExpand
Purine and pyrimidine receptors
  • G. Burnstock
  • Medicine, Biology
  • Cellular and Molecular Life Sciences
  • 19 March 2007
Abstract.Adenosine 5′-triphosphate (ATP), in addition to its intracellular roles, acts as an extracellular signalling molecule via a rich array of receptors, which have been cloned and characterised.Expand
Nomenclature and classification of purinoceptors.
TLDR
The evidence is now compelling that ATP plays important physiological and/ or pathophysiological roles in a variety of biological systems, and the presence of receptors for ADP and adenosine (presumably A2) receptors exist on platelets is compelling. Expand
A P2X purinoceptor expressed by a subset of sensory neurons
TLDR
The remarkable selectivity of expression of the channel coupled with its sensory neuron-like pharmacology suggests that this channel may transduce ATP-evoked nociceptor activation. Expand
Purinergic signalling in the nervous system: an overview
TLDR
Recent data involving purinergic signalling in pathological conditions, including pain, trauma, ischaemia, epilepsy, migraine, psychiatric disorders and drug addiction are highlighted, which are expected to lead to the development of therapeutic strategies for these disorders with novel mechanisms of action. Expand
Purinergic signalling in neuron–glia interactions
TLDR
The involvement of ATP and adenosine receptors in neuron–glia signalling, including the release and hydrolysis of ATP, how the receptors signal, the pharmacological tools used to study them, and their functional significance are reviewed. Expand
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X 3-deficient mice
TLDR
P2X3 is critical for peripheral pain responses and afferent pathways controlling urinary bladder volume reflexes and may have therapeutic potential in the treatment of disorders of urine storage and voiding such as overactive bladder. Expand
International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.
TLDR
The structure, distribution, function, and ligand recognition characteristics of P2X receptors, which comprise seven distinct subunits that can function as both homo- and hetero- polymers, are described. Expand
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