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Establishment and identification of small cell lung cancer cell lines having classic and variant features.
Using a chemically defined medium containing hydrocortisone, insulin, transferrin, 17 beta-estradiol and selenium, with or without serum supplementation (2.5% v/v), continuous cell lines can beExpand
Neurons switch from non-neuronal enolase to neuron-specific enolase during differentiation
TLDR
Investigation of neurons in cerebellum and neocortex reveals that they are NNE(+) during migration and only become NSE(+) in their final location, presumably after making full synaptic connections. Expand
Evidence for the presence of S-100 protein in the glial component of the human enteric nervous system
TLDR
It is demonstrated here, using immunohistochemistry and electron immunocytochemistry, that both enteric glial cells and Schwann cells of the human gut contain densely immunoreactive S-100, and this protein can therefore be regarded as a common marker for the glial components of the enteric nervous system. Expand
Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes
TLDR
It is concluded that AICA riboside exerts a suppressive effect on gluconeogenesis because it provokes an accumulation of ZMP, which inhibits fructose-1,6-bisphosphatase. Expand
Neurone-specific enolase is a molecular marker for peripheral and central neuroendocrine cells
TLDR
It is reported that NSE is also present in peripheral and central neuroendocrine cells, also termed amine precursor uptake and decarboxylation (APUD) cells, and the results in human tissues suggest that the immunocytochemical localisation in rat and monkey will be valid for man and prove useful in the study of human diseases involving the APUD cell class. Expand
Brain endolases as specific markers of neuronal and glial cells.
TLDR
Light microscopy with immunocytochemical techniques has permitted localization of non-neuronal enolase, and it is found that NSE and NNE can be used as specific metabolic markers for neurons and glial cells, respectively. Expand
Autoradiographic localization of adenosine uptake sites in rat brain using [3H]nitrobenzylthioinosine
TLDR
The localization of theAdenosine uptake site in brain may provide information on the functional activity of the site and suggests the involvement of the adenosine system in the central regulation of cardiovascular function. Expand
Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro 5-4864.
TLDR
The results indicate that the peripheral-type benzodiazepine binding site in brain is a separate entity whose physiological function is probably distinct from that of the central-type Benzodiazepines receptor. Expand
SERUM NEURON-SPECIFIC ENOLASE: A MARKER FOR DISEASE EXTENT AND RESPONSE TO THERAPY OF SMALL-CELL LUNG CANCER
TLDR
Serum neuron-specific enolase levels in 94 newly diagnosed untreated patients with small-cell lung cancer were compared with those in 30 adult controls to indicate that serum NSE may be a useful marker for staging and for monitoring response to therapy in patients with SCLC. Expand
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