• Publications
  • Influence
Adenosine receptor activation and nociception.
  • J. Sawynok
  • Biology
    European journal of pharmacology
  • 17 April 1998
Adenosine receptor targets for pain
  • J. Sawynok
  • Biology, Medicine
    Neuroscience
  • 3 December 2016
Topical and Peripherally Acting Analgesics
  • J. Sawynok
  • Biology
    Pharmacological Reviews
  • 1 March 2003
TLDR
The localized peripheral administration of drugs, such as by topical application, can potentially optimize drug concentrations at the site of origin of the pain, while leading to lower systemic levels and fewer adverse systemic effects, fewer drug interactions, and no need to titrate doses into a therapeutic range compared with systemic administration.
Topical 2% Amitriptyline and 1% Ketamine in Neuropathic Pain Syndromes: A Randomized, Double-blind, Placebo-controlled Trial
TLDR
This randomized, placebo-controlled trial examining topical 2% amitriptyline, 1% ketamine, and a combination in the treatment of neuropathic pain revealed no difference between groups.
The therapeutic use of heroin: a review of the pharmacological literature.
  • J. Sawynok
  • Biology, Medicine
    Canadian journal of physiology and pharmacology
  • 1986
TLDR
In animal studies, heroin and 6-acetylmorphine are both more potent and faster acting than morphine as analgesics, effects attributed to their greater lipid solubility and subsequent penetration of the blood-brain barrier.
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