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The IL-1 family cytokines are regulated on transcriptional and posttranscriptional levels. Pattern recognition and cytokine… Expand Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human… Expand IL-23 is a heterodimeric cytokine composed of the IL-12p40 “soluble receptor” subunit and a novel cytokine-like subunit related… Expand The anti-inflammatory cytokines are a series of immunoregulatory molecules that control the proinflammatory cytokine response… Expand A variety of cytokines activate receptor-associated members of the Janus family of protein tyrosine kinases (Jaks). To assess the… Expand During the last several years, the mechanism of IFN gamma-dependent signal transduction has been the focus of intense… Expand Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon… Expand Many cytokines mediate their biological effects through interaction with a distinct family of receptors termed the cytokine… Expand Many members of the cytokine receptor superfamily initiate intracellular signaling by activating members of the Jak family of… Expand A family of cytokine receptors comprising molecules specific for a diverse group of hematopoietic factors and growth hormones has… Expand