Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.

@article{Yao1995HerpesvirusSE,
  title={Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.},
  author={Zhengbin Yao and William C. Fanslow and Michael F. Seldin and Annita M J Rousseau and Sally L Painter and Michael R. Comeau and Jeffrey I. Cohen and Melanie K. Spriggs},
  journal={Immunity},
  year={1995},
  volume={3 6},
  pages={811-21}
}
Herpesvirus Saimiri gene 13 (HVS13) exhibits 57% identity with the predicted sequence of a T cell-derived molecule termed CTLA8. Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappa B activity and interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation. An HVS13.Fc fusion protein was used to isolate a cDNA encoding a novel receptor that also binds CTLA8. This receptor is unrelated to previously identified cytokine receptor families. A recombinant… CONTINUE READING
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