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Raxofelast

Known as: 2-(2,3-dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl)acetic acid, 2-Benzofuranacetic acid, 5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-, (+-)- 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

BenzofuransVitamin E

Narrower (1)

IRFI 016
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Lipid peroxidation activates mitogen-activated protein kinases in testicular ischemia-reperfusion injury.
2005
2005
LIPID PEROXIDATION INHIBITION BY RAXOFELAST IMPROVES ANGIOGENESIS AND WOUND HEALING IN EXPERIMENTAL BURN WOUNDS
We investigated the effects of raxofelast, a lipid peroxidation inhibitor, in an experimental model of burn wounds. C57BL/6 male… 
2005
2005
Protective Effects of Antioxidant Raxofelast in Alcohol-Induced Liver Disease in Mice
We investigated the effect of raxofelast on lipid peroxidation inhibition in mice exposed to chronic ethanol. Female C57BL/6 mice… 
Highly Cited
2004
Highly Cited
2004
Raxofelast, a hydrophilic vitamin e-like antioxidant, reduces testicular ischemia-reperfusion injury
Testis torsion is a surgical emergency that lead to permanent gonad damage. The damage has been ascribed to mechanisms of… 
Highly Cited
2001
Highly Cited
2001
Raxofelast, a hydrophilic vitamin E-like antioxidant, stimulates wound healing in genetically diabetic mice.
BACKGROUND Impaired wound healing is a well-documented phenomenon in experimental and clinical diabetes. Emerging evidence favors… 
Highly Cited
2001
Highly Cited
2001
Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse.
Impaired wound healing is a well-documented phenomenon in experimental and clinical diabetes. Experimental evidence suggests that… 
Highly Cited
2000
Highly Cited
2000
Oral treatment with an antioxidant (raxofelast) reduces oxidative stress and improves endothelial function in men with Type II diabetes
Aims/hypothesis. To determine whether raxofelast, a new water soluble antioxidant decreases oxidative stress and improves… 
Highly Cited
1999
Highly Cited
1999
Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E‐like antioxidant, in carrageenan‐induced pleurisy
Peroxynitrite is a strong oxidant that results from reaction between NO and superoxide. It has been recently proposed that… 
1999
1999
Protection of low density lipoprotein oxidation by the antioxidant agent IRFI005, a new synthetic hydrophilic vitamin E analogue.
1998
1998
Beneficial effect of raxofelast, an hydrophilic vitamin E analogue, in the rat heart after ischemia and reperfusion injury.
Several studies report that among the antioxidant agents used to reduce injury after myocardial ischemia/reperfusion, analogues… 
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