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Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats
TLDR
Treatment with HYA and C4S limited the erosive action of the disease in the articular joints of knee and paw, reduced lipid peroxidation, restored the endogenous antioxidants reduced glutathione (GSH) and superoxide dismutase, decreased plasma TNF-α levels, and limited synovial neutrophil infiltration. Expand
The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women.
TLDR
Genistein therapy improves flow-mediated endothelium dependent vasodilation in healthy postmenopausal women and may be mediated by a direct effect of genistein on the vascular function and could be the result of an increased ratio of nitric oxide to endothelin. Expand
Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse.
TLDR
Evidence is provided that lipid peroxidation inhibition restores wound healing to nearly normal levels in experimental diabetes-impaired wounds and normalizes the defect in VEGF regulation associated with diabetes-induced skin-repair disorders. Expand
Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats.
TLDR
Genistein supplementation enhanced the circulating levels of the phytoestrogen and affected NOS activity and endothelial dysfunction to the same extent and 17 beta-estradiol show overlapping effects on experimental endothelial function. Expand
Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes.
TLDR
Adding HA fragments to chondrocyte cultures up-regulated CD44 and TLR-4 expression, activated NF-kappaB translocation and increased the pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1beta. Expand
Effects of Hypericum perforatum on Levels of 5‐Hydroxytryptamine, Noradrenaline and Dopamine in the Cortex, Diencephalon and Brainstem of the Rat
TLDR
This work has investigated the contribution of hypericin and flavonoids to the antidepressant effects of hypericum and found that these compounds have antidepressant properties. Expand
Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes.
TLDR
It is suggested that HA may modulate proinflammatory cytokines via its different degree of polymerization and inflammatory action may be modulated as a result of the interaction between HA and TLR-4. Expand
Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes.
TLDR
The regulatory effect exerted by HA (at any MW) on NF-kB activation may depend upon the interaction between HA and TLR-4 and HA may thereby modulate pro-inflammatory activity via its different state of aggregation. Expand
Glycosaminoglycans modulate inflammation and apoptosis in LPS‐treated chondrocytes
TLDR
The results of this study give further support to the hypothesis that GAGs actively participate in the regulation of inflammatory and apoptotic processes. Expand
Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis.
TLDR
The results indicate that the L-arginine/NO pathway is involved in mediating leptin effects on feeding behavior, and demonstrate that nNOS activity is required for the effects of leptin on brain 5-HT turnover. Expand
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