Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats
- G. Campo, A. Avenoso, S. Campo, A. Ferlazzo, D. Altavilla, A. Calatroni
- Biology, MedicineArthritis Research & Therapy
- 6 March 2003
Treatment with HYA and C4S limited the erosive action of the disease in the articular joints of knee and paw, reduced lipid peroxidation, restored the endogenous antioxidants reduced glutathione (GSH) and superoxide dismutase, decreased plasma TNF-α levels, and limited synovial neutrophil infiltration.
The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women.
Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes.
Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats.
Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse.
Evidence is provided that lipid peroxidation inhibition restores wound healing to nearly normal levels in experimental diabetes-impaired wounds and normalizes the defect in VEGF regulation associated with diabetes-induced skin-repair disorders.
Effects of Hypericum perforatum on Levels of 5‐Hydroxytryptamine, Noradrenaline and Dopamine in the Cortex, Diencephalon and Brainstem of the Rat
This work has investigated the contribution of hypericin and flavonoids to the antidepressant effects of hypericum and found that these compounds have antidepressant properties.
Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes.
It is suggested that HA may modulate proinflammatory cytokines via its different degree of polymerization and inflammatory action may be modulated as a result of the interaction between HA and TLR-4.
Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis.
The results indicate that the L-arginine/NO pathway is involved in mediating leptin effects on feeding behavior, and demonstrate that nNOS activity is required for the effects of leptin on brain 5-HT turnover.
Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes.
Glycosaminoglycans modulate inflammation and apoptosis in LPS‐treated chondrocytes
The results of this study give further support to the hypothesis that GAGs actively participate in the regulation of inflammatory and apoptotic processes.