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Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury.
TLDR
Treatment with either peroxynitrite decomposition catalysts and selective superoxide dismutase mimetics, or with SODm, have been shown to prevent in vivo the delayed vascular decompensation and the cellular energetic failure associated with shock, inflammation, and ischemia/reperfusion injury. Expand
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
TLDR
Experimental data is summarized that outline how the discovery that NO modulates prostaglandin production has impacted and extended the understanding of these two systems in physiopathological events. Expand
Melatonin is a scavenger of peroxynitrite.
TLDR
It is demonstrated that the pineal neurohormone melatonin inhibits peroxynitrite-mediated oxidant processes and may contribute to the antioxidant and antiinflammatory effects of melatonin in various pathophysiological conditions. Expand
A role for superoxide in gentamicin-mediated nephropathy in rats.
TLDR
The hypothesis that superoxide anions play an important role in gentamicin-mediated nephropathy is confirmed and the possible clinical use of low molecular weight synthetic superoxide dismutase mimetics in those conditions that are associated with over production of superoxide is supported. Expand
A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats.
TLDR
A manganese(II) complex with a bis(cyclohexylpyridine)-substituted macrocyclic ligand was designed to be a functional mimic of the superoxide dismutase (SOD) enzymes that normally remove these radicals. Expand
A Newly Identified Role for Superoxide in Inflammatory Pain
TLDR
A critical role for superoxide is unraveled in the nociceptive signaling cascade both peripherally and centrally and the discovery of this pathway opens a new therapeutic strategy for the development of novel nonnarcotic antihyperalgesic agents. Expand
Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease
TLDR
Chronic treatment with palmitoylethanolamide (PEA) protects against MPTP-induced neurotoxicity and the ensuing functional deficits even when administered once the insult has been initiated, and chronic PEA reversedMPTP-associated motor deficits. Expand
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat.
TLDR
In vivo and in vitro, tempol significantly reduced the increase in urea, creatinine, gammaGT, AST, NAG, and FENa produced by renal ischemia/reperfusion, suggesting an improvement in both renal function and injury. Expand
On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies
TLDR
This review will discuss the advances made using various superoxide dismutase mimetics that led to the proposal that superoxide (and/or the product of its interaction with nitric oxide, peroxynitrite) is an important mediator of inflammation, and to the conclusion that super poisoning mimetics can be utilized as therapeutic agents in diseases of various etiologies. Expand
Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase.
TLDR
It is demonstrated that topically administered sodium nitrite protects the rat kidney against I/R injury and dysfunction in vivo via the generation, in part, of xanthine oxidoreductase-catalyzed NO production. Expand
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