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Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury.
TLDR
Treatment with either peroxynitrite decomposition catalysts and selective superoxide dismutase mimetics, or with SODm, have been shown to prevent in vivo the delayed vascular decompensation and the cellular energetic failure associated with shock, inflammation, and ischemia/reperfusion injury. Expand
Adherence to Antihypertensive Medications and Cardiovascular Morbidity Among Newly Diagnosed Hypertensive Patients
TLDR
The long-term reduction of acute cardiovascular events associated with high adherence to antihypertensive treatment underscores its importance in assessments of the beneficial effects of evidence-based therapies in the population. Expand
A role for superoxide in gentamicin-mediated nephropathy in rats.
TLDR
The hypothesis that superoxide anions play an important role in gentamicin-mediated nephropathy is confirmed and the possible clinical use of low molecular weight synthetic superoxide dismutase mimetics in those conditions that are associated with over production of superoxide is supported. Expand
Allele and genotype frequencies of CYP2C9, CYP2C19 and CYP2D6 in an Italian population.
TLDR
The genotype profile of a random Italian population is determined in order to compare the CYP2C9, CYP 2C19 and CYP1D6 allele frequencies among Italians with previous findings in other Caucasian populations and confirms the higher frequency of CYp2D6 UM in the Mediterranean area compared to Northern Europe. Expand
Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.
TLDR
In vivo recombinant human erythropoietin effects on brain ischemic injury could be due to inhibition of NO overproduction, as indicated by reduction in nitrite and nitrate in the hippocampus, as observed after ischemia. Expand
Intake of energy drinks in association with alcoholic beverages in a cohort of students of the School of Medicine of the University of Messina.
TLDR
The data indicate that association of ED + alcohol is very popular among students and can be dangerous, as the combination of ED and alcoholic drinks can reduce adversive symptoms of alcohol intoxication including the depressant effects. Expand
Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation
TLDR
It is shown for the first time that prevention of the activation of NF‐κB by PDTC reduces the development of acute and chronic inflammation. Expand
The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women.
TLDR
Genistein therapy improves flow-mediated endothelium dependent vasodilation in healthy postmenopausal women and may be mediated by a direct effect of genistein on the vascular function and could be the result of an increased ratio of nitric oxide to endothelin. Expand
Cutaneous reactions to drugs. An analysis of spontaneous reports in four Italian regions.
TLDR
Spontaneous reports from four Italian regions revealed that the skin was the organ most frequently affected by ADRs, and the paper shows the validity of a regional decentralized system in Italy. Expand
Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation.
TLDR
It is proposed that rosiglitazone and other potent PPAR-gamma agonists may be useful in the therapy of inflammation. Expand
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