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RTI-55

Known as: RTI 55 
 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.
In previous studies examining the structural determinants of antidepressant and substrate recognition by serotonin transporters… Expand
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Highly Cited
2004
Highly Cited
2004
Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.
Serotonin (5-hydroxytryptamine; 5-HT) transporters (SERTs) are critical determinants of synaptic 5-HT inactivation and the… Expand
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2000
2000
Reinstatement of extinguished drug-taking behavior in rats: effect of the kappa-opioid receptor agonist, U69593
Abstract. Rationale: Results of a previous study indicated that prior administration of the kappa-opioid receptor agonist, U69593… Expand
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2000
2000
Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects
Abstract  Rationale: The discriminative-stimulus effects of cocaine have been reported to be mediated by indirect agonist actions… Expand
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Highly Cited
1999
Highly Cited
1999
Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type.
We characterized the effects of drugs on the uptake of [3H]neurotransmitter by and the binding of [125I](3beta-(4-iodophenyl… Expand
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Highly Cited
1996
Highly Cited
1996
Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies.
In our study, age-matched Holtzman Sprague-Dawley rats (275-300 g) received injections with either saline (0.9%) or 3,4… Expand
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1995
1995
IPT: a novel iodinated ligand for the CNS dopamine transporter.
An iodinated cocaine derivative, N-(3'-iodopropen-2'-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl) tropane (IPT), was evaluated… Expand
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Highly Cited
1994
Highly Cited
1994
Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster.
We report here on the isolation and characterization of a serotonin (5HT) transporter from Drosophila melanogaster. A 3.1-kb… Expand
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1994
1994
Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate membranes for the cocaine analog [125I]RTI-55.
The drug 3 beta-[4'-iodophenyl]tropan-2 beta-carboxylic acid methyl ester (RTI-55) is a cocaine congener with high affinity for… Expand
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1993
1993
[125I]RTI-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain.
[125I]RTI-55 is a newly synthesized cocaine congener that may offer advantages over other ligands previously used to examine… Expand
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