• Publications
  • Influence
Amphetamine‐type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
A large body of evidence supports the hypothesis that mesolimbic dopamine (DA) mediates, in animal models, the reinforcing effects of central nervous system stimulants such as cocaine andExpand
  • 826
  • 58
  • PDF
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in
RationaleStress and depression have been linked to relapse of cocaine abuse. Antagonism of the kappa opioid receptor (KOR) has been reported to attenuate some effects of stressors, and antagonism ofExpand
  • 251
  • 29
Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults.
BACKGROUND Community-acquired pneumonia is a leading infectious cause of hospitalization and death among U.S. adults. Incidence estimates of pneumonia confirmed radiographically and with the use ofExpand
  • 769
  • 22
  • PDF
Structure of the human kappa opioid receptor in complex with JDTic
Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the regulation of pain, respiratory drive, mood, and—in the case of κ-opioidExpand
  • 536
  • 19
  • PDF
Preferential Increases in Nucleus Accumbens Dopamine after Systemic Cocaine Administration Are Caused by Unique Characteristics of Dopamine Neurotransmission
In vivo voltammetry was used to investigate the preferential increase of extracellular dopamine in the nucleus accumbens relative to the caudate-putamen after systemic cocaine administration. In theExpand
  • 111
  • 19
  • PDF
Structure of the human k-opioid receptor in complex with JDTic
Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the regulation of pain, respiratory drive, mood, and—in the case of k-opioidExpand
  • 300
  • 17
  • PDF
Buprenorphine-Induced Antinociception Is Mediated by μ-Opioid Receptors and Compromised by Concomitant Activation of Opioid Receptor-Like Receptors
Buprenorphine is a mixed opioid receptor agonist-antagonist used clinically for maintenance therapy in opiate addicts and pain management. Dose-response curves for buprenorphine-inducedExpand
  • 208
  • 17
Enantioselective Effects of Hydroxy Metabolites of Bupropion on Behavior and on Function of Monoamine Transporters and Nicotinic Receptors
Bupropion is an atypical antidepressant that also has usefulness as a smoking-cessation aid. Because hydroxybupropion, a major metabolite of bupropion, is believed to contribute to its antidepressantExpand
  • 188
  • 17
  • PDF
Varenicline Is a Partial Agonist at α4β2 and a Full Agonist at α7 Neuronal Nicotinic Receptors
Varenicline, a new nicotinic ligand based on the structure of cytisine, has recently been approved by the U.S. Food and Drug Administration for use as a smoking cessation aid. Varenicline has beenExpand
  • 467
  • 16
  • PDF
Anxiolytic-Like Effects of κ-Opioid Receptor Antagonists in Models of Unlearned and Learned Fear in Rats
Endogenous opioid systems regulate neurobiological responses to threatening stimuli. Stimulation of κ-opioid receptors (KORs) produces analgesia but induces prodepressive-like effects in a variety ofExpand
  • 200
  • 15
  • PDF