• Publications
  • Influence
Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
TLDR
Although no differences were observed in the striatum relative to control subjects, binding of radioligand to D1R was reduced in the prefrontal cortex of schizophrenics, and this reduction was related to the severity of the negative symptoms and to poor performance in the Wisconsin Card Sorting Test. Expand
Age-related changes in human D1 dopamine receptors measured by positron emission tomography
TLDR
The effects of age on the binding parameters of11C-SCH23390, the highly selective ligand for central D1 dopamine receptors, at specific binding sites in the brain were studied and quantitative estimates of rate constants of association and dissociation were obtained. Expand
Brain muscarinic receptors in progressive supranuclear palsy and Parkinson’s disease: a positron emission tomographic study
TLDR
The increased mAChR binding in the frontal cortex of the patients with Parkinson’s disease may reflect denervation hypersensitivity caused by loss of the ascending cholinergic input to that region from the basal forebrain and may be related to frontal lobe dysfunction in Parkinson's disease. Expand
In Vivo Expression of Cyclooxygenase-1 in Activated Microglia and Macrophages During Neuroinflammation Visualized by PET with 11C-Ketoprofen Methyl Ester
TLDR
11C-ketoprofen methyl ester is identified as a COX-1–selective PET probe and a time-dependent expression of COx-1 in activated microglia and macrophages during the neuroinflammatory process in the living brain is demonstrated. Expand
Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging
TLDR
Regional activation of the brain was studied in humans using functional magnetic resonance imaging during whole body cooling that produced thermal comfort/discomfort to suggest that the amygdala plays a role in the genesis of thermal discomfort due to cold. Expand
Dopamine D1 receptors in Parkinson's disease and striatonigral degeneration: a positron emission tomography study.
TLDR
The results may explain the different therapeutic responses to levadopa between SND and PD patients, and this technique might prove useful for their differentiation. Expand
Reserpine-induced reduction of in vivo binding of SCH 23390 and N-methylspiperone and its reversal by d-amphetamine.
TLDR
It is suggested that dopamine D2 receptor-mediated neurotransmission might itself regulate the binding of dopamine to receptors in vivo, and treatment with haloperidol did prevent the effect of d-amphetamine on [3H]SCH23390 binding. Expand
Computer-controlled large scale production of high specific activity [11C]RO 15-1788 for PET studies of benzodiazepine receptors.
TLDR
Each product was sufficient to carry out three successive clinical studies by positron emission tomography (PET) and all the procedures other than evaporation and filtration at the final stage were carried out with specially designed equipment connected to a central control system for radioisotope production. Expand
Ketamine increases the striatal N-[11C]methylspiperone binding in vivo: positron emission tomography study using conscious rhesus monkey
TLDR
Results indicate that ketamine facilitates striatal dopaminergic neurotransmission through increasing the binding activity of dopamine D2 receptors in the striatum, and suggest that these changes may be related to the psychotomimetic behavioral symptoms of this drug. Expand
Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors
TLDR
All three stressors caused an immediate, significant and reversible increase of extracellular 5-HT levels in both brain structures, suggesting a more dynamic role played by the serotonergic system in response to acute stress. Expand
...
1
2
3
4
5
...