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N-Substituted Piperazines Abused by Humans Mimic the Molecular Mechanism of 3,4-Methylenedioxymethamphetamine (MDMA, or ‘Ecstasy’)
TLDR
The results show that BZP/TFMPP and MDMA share the ability to evoke monoamine release, but dangerous drug–drug synergism may occur when piperazines are coadministered at high doses. Expand
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
TLDR
It is found that long-term MDMA use could lead to the development of fenfluramine-like VHD, and the necessity of screening current and future drugs at h5-HT2B receptors for agonist actions before their use in humans is underscored. Expand
Enantioselective Effects of Hydroxy Metabolites of Bupropion on Behavior and on Function of Monoamine Transporters and Nicotinic Receptors
TLDR
The results suggest that clinical and behavioral effects of bupropion arise from actions at nAChR as well as DA and NE transporters and that the (2S,3S)-hydroxybupropion isomer may be a better drug candidate for smoking cessation because of its higher potency at the relevant targets. Expand
Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs
TLDR
The results suggest that the mechanism for this effect involves a decrease in reinforcing potency and efficacy among monoamine releasing agents when 5-HT releasing potency is increased relative to DA. Expand
Effects of synthetic cathinones contained in "bath salts" on motor behavior and a functional observational battery in mice.
TLDR
Results suggest that individual synthetic cathinones differ in their profile of effects, and differ from known stimulants of abuse, suggesting that they may be just as harmful as the ones that have been banned. Expand
Interaction of Amphetamines and Related Compounds at the Vesicular Monoamine Transporter
TLDR
The data strongly suggest that amphetamine-type agents deplete vesicular neurotransmitter via a carrier-mediated exchange mechanism rather than via a weak base effect, although this conclusion needs to be confirmed via direct measurement of vesicle pH. Expand
Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)
TLDR
Findings represent the first evidence that second generation analogs of MDPV are catecholamine-selective uptake blockers which may pose risk for addiction and adverse effects in human users. Expand
Use of intracranial self‐stimulation to evaluate abuse‐related and abuse‐limiting effects of monoamine releasers in rats
TLDR
The purpose of this study was to further elucidate the role of dopamine versus serotonin selectivity on expression of abuse‐related effects produced by monoamine releasers in an assay of intracranial self‐stimulation (ICSS) in rats. Expand
The Reinforcing and Rewarding Effects of Methylone, a Synthetic Cathinone Commonly Found in "Bath Salts"
TLDR
Results reveal that methylone may possess an addiction potential similar to or greater than MDMA, yet patterns of self-administration and effects on brain reward function suggest that this drug may have a lower potential for abuse and compulsive use than prototypical psychostimulants. Expand
Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter.
TLDR
Mechanisms of atypical DAT inhibitors may serve as targets for the development of treatments for stimulant abuse, and these mechanisms are novel and their further exploration may produce compounds with unique therapeutic potential as treatments for Stimulant abuse. Expand
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