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RNA-Directed DNA Polymerase

Known as: RNA Transcriptase, Deoxynucleotide-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed), DNA Polymerase, RNA Directed 
An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49… 
National Institutes of Health

Related topics

Related topics

30 relations

Broader (2)

DNA Nucleotidyltransferasesnucleotidyltransferase
DNA-Directed RNA PolymeraseEnzyme GeneGene Products, polHIV nonnucleoside reverse transcriptase gene mutations detected:Prid:Pt:Isolate:Nom

Narrower (6)

LtrA protein, Lactococcus lactisaI1 endonucleaseaI2 protein, S cerevisiaematurase I-AniI

Papers overview

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Highly Cited
2004
Highly Cited
2004
Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis.
Highly Cited
2002
Highly Cited
2002
Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation
ABSTRACT The human cytotoxic T-lymphocyte (CTL) response to human immunodeficiency virus type 1 (HIV-1) has been intensely… 
Highly Cited
1999
Highly Cited
1999
Retrotransposon BARE-1 and Its Role in Genome Evolution in the Genus Hordeum
The replicative retrotransposon life cycle offers the potential for explosive increases in copy number and consequent inflation… 
Highly Cited
1999
Highly Cited
1999
Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART).
Peptide/MHC tetrameric complexes were used to enumerate the frequency of HLA class I-restricted epitope-specific CD8+ T cells in… 
Highly Cited
1999
Highly Cited
1999
Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy.
BACKGROUND This study addresses the dynamic of viral load rebound and immune system changes in a cohort of eight consecutive HIV… 
Highly Cited
1997
Highly Cited
1997
Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation.
Activation of T cells is induced efficiently by dendritic cells (DC), but little is known about the role of DC in the regulation… 
Highly Cited
1995
Highly Cited
1995
TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines.
The inflammatory cytokines IFN-gamma and TNF-alpha have been demonstrated in various autoimmune diseases, and are thought to… 
Highly Cited
1993
Highly Cited
1993
Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution
The crystal structure of T7 RNA polymerase reveals a molecule organized around a cleft that can accommodate a double-stranded DNA… 
Highly Cited
1990
Highly Cited
1990
Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations.
We determined the in vivo forward mutation rate in a single replication cycle for spleen necrosis virus (SNV). A method was… 
Highly Cited
1981
Highly Cited
1981
Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins.
The nucleotide sequence of intracellular 26S mRNA of Sindbis virus has been determined by direct sequence analysis of the cDNA… 
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