W. Haseltine

Publications265
h-index78
Citations26,762
Highly Influential Citations601
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Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer
HEREDITARY nonpolyposis colorectal cancer (HNPCC) is one of man's commonest hereditary diseases1. Several studies have implicated a defect in DNA mismatch repair in the pathogenesis of this… Expand
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Complete nucleotide sequence of the AIDS virus, HTLV-III
The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The… Expand
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Mutation of a mutL homolog in hereditary colon cancer.
Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A search of a large database of expressed sequence tags derived from… Expand
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Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.
Mutations in sequences at the C terminus of the capsid precursor protein of human immunodeficiency virus type 1 that affect the viral p6 protein prevent release of budded virus particles from the… Expand
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Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.
The effects on human immunodeficiency virus type 1 virion morphogenesis and on virus replication of mutations that affect posttranslational processing of the capsid precursor protein are described. A… Expand
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Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes.
The viral infectivity factor gene vif of human immunodeficiency virus type 1 has been shown to affect the infectivity but not the production of virus particles. In this study, the effect of vif in… Expand
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Synthesis of guanosine tetra- and pentaphosphate requires the presence of a codon-specific, uncharged transfer ribonucleic acid in the acceptor site of ribosomes.
The nucleotides ppGpp and pppGpp accumulate when wild-type, but not rel(-), strains of Escherichia coli are starved for required amino acids. These compounds are synthesized on ribosomes, in the… Expand
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Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors.
The reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) is the major target for antiretroviral therapy of the acquired immunodeficiency syndrome (AIDS). While some… Expand
  • 139
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Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex.
Cytoplasmic extracts prepared from cells infected with metabolically radiolabeled virions of human immunodeficiency virus type 1 contain viral DNA in association with labeled viral proteins. Viral… Expand
  • 291
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Integration of human immunodeficiency virus type 1 DNA in vitro.
A highly efficient cell-free system for the integration of human immunodeficiency virus type 1 DNA is described. Linear viral DNA synthesis occurs in the cytoplasm of newly infected cells, reaching… Expand
  • 234
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