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The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins
The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to theseExpand
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Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: “waiting for Godot”
Genome-wide sequence analysis in the invertebrate chordate, Ciona intestinalis, has provided a comprehensive picture of immune-related genes in an organism that occupies a key phylogenetic positionExpand
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Proteolytic cascades and their involvement in invertebrate immunity.
Bacteria and other potential pathogens are cleared rapidly from the body fluids of invertebrates by the immediate response of the innate immune system. Proteolytic cascades, following theirExpand
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The amphioxus genome illuminates vertebrate origins and cephalochordate biology.
Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution and the origin of vertebrates, weExpand
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Multi-component complement system of Cnidaria: C3, Bf, and MASP genes expressed in the endodermal tissues of a sea anemone, Nematostella vectensis.
The origin of the complement system, one of the major systems of mammalian innate immunity, is more ancient than that of the adaptive immune system, as shown by the identification of the gene for theExpand
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A detailed linkage map of medaka, Oryzias latipes: comparative genomics and genome evolution.
We mapped 633 markers (488 AFLPs, 28 RAPDs, 34 IRSs, 75 ESTs, 4 STSs, and 4 phenotypic markers) for the Medaka Oryzias latipes, a teleost fish of the order Beloniformes. Linkage was determined usingExpand
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Ancestral Organization of the MHC Revealed in the Amphibian Xenopus1
With the advent of the Xenopus tropicalis genome project, we analyzed scaffolds containing MHC genes. On eight scaffolds encompassing 3.65 Mbp, 122 MHC genes were found of which 110 genes wereExpand
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Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co‐evolution among MHC class I region genes
In the frog Xenopus, MHC class I antigen presentation and processing genes (the immunoproteasome LMP2 and LMP7 and the transporter TAP1 and TAP2) seemto be closely linked in a primordialExpand
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A Three-step Proteolytic Cascade Mediates the Activation of the Peptidoglycan-induced Toll Pathway in an Insect*
The recognition of lysine-type peptidoglycans (PG) by the PG recognition complex has been suggested to cause activation of the serine protease cascade leading to the processing of Spätzle andExpand
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Gene expression profile during the life cycle of the urochordate Ciona intestinalis.
Recent whole-genome studies and in-depth expressed sequence tag (EST) analyses have identified most of the developmentally relevant genes in the urochordate, Ciona intestinalis. In this study, weExpand
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