Skip to search formSkip to main contentSkip to account menu

RBBP8 protein, human

Known as: CtBP-Interacting Protein, Sporulation in the Absence of SPO11 Protein 2 Homolog, retinoblastoma binding protein 8, human 
Retinoblastoma binding protein 8 (897 aa, ~102 kDa) is encoded by the human RBBP8 gene. This protein is involved in cell cycle checkpoint control.
National Institutes of Health

Related topics

Related topics

17 relations

Broader (3)

Carrier ProteinsEsterasesNuclear Proteins
Cell Cycle CheckpointsCell Cycle ControlDNA RepairDNA Repair Endonuclease

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance
Significance Poly(ADP-ribose) polymerase (PARP) inhibitors have produced responses in homologous recombination (HR) repair… 
Highly Cited
2011
Highly Cited
2011
Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks
The multifunctional Mre11-Rad50-Nbs1 (MRN) protein complex recruits ATM/Tel1 checkpoint kinase and CtIP/Ctp1 homologous… 
Review
2011
Review
2011
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
Genomic instability is a common feature of cancer etiology. This provides an avenue for therapeutic intervention, since cancer… 
Highly Cited
2010
Highly Cited
2010
Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair
Topoisomerase inhibitors such as camptothecin and etoposide are used as anti-cancer drugs and induce double-strand breaks (DSBs… 
Highly Cited
2009
Highly Cited
2009
A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage
Highly Cited
2007
Highly Cited
2007
Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.
Highly Cited
2004
Highly Cited
2004
DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains
ABSTRACT The BRCA1 C-terminal (BRCT) domain has recently been implicated as a phospho-protein binding domain. We demonstrate here… 
Highly Cited
1999
Highly Cited
1999
A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor.
Previous work has demonstrated the critical role for transcription repression in quiescent cells through the action of E2F-Rb or… 
Highly Cited
1999
Highly Cited
1999
Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage*
Mutations in BRCA1 are responsible for nearly all of the hereditary ovarian and breast cancers, and about half of those in breast… 
Highly Cited
1998
Highly Cited
1998
The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression*
The BRCA1 tumor suppressor encodes a polypeptide with two recognizable protein motifs: a RING domain near the N terminus and two… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)