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RAP1A protein, human

Known as: RAICHU404X protein, human, SMGP21, G-22K 
Encoded by human RAP1A Gene (RAS GTPase Family), 184-aa 21-kDa (precursor) membrane-bound RAS-Related Protein RAP1A is activated by guanine… 
National Institutes of Health

Related topics

Related topics

10 relations
Focal adhesion pathwayHepatocyte Growth Factor Receptor Signaling PathwayIntegrin Signaling PathwayRAP1A gene

Broader (2)

rap1 GTP-Binding Proteinsrap1A GTP-Binding Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth
Tumor inflammation, the recruitment of myeloid lineage cells into the tumor microenvironment, promotes angiogenesis… 
Highly Cited
2005
Highly Cited
2005
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils
Through chemical screening, we identified a pyrazolone that reversibly blocked the activation of phagocyte oxidase (phox) in… 
Review
2003
Review
2003
GTPases and T cell activation
Summary:  Guanine nucleotide binding proteins rapidly cycle between a guanosine diphosphate (GDP)‐bound and guanosine… 
Highly Cited
2003
Highly Cited
2003
Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form
We recently showed that rap1 regulates growth and proliferation in normal keratinocytes, which provoked us to investigate its… 
Highly Cited
2002
Highly Cited
2002
Isoprenoids influence expression of Ras and Ras-related proteins.
Mevalonate depletion by inhibition of hydroxymethylglutaryl coenzyme A reductase impairs post-translational processing of Ras and… 
Highly Cited
2002
Highly Cited
2002
Consequences of Mevalonate Depletion
Ras-related proteins are small GTPases that are post-translationally modified with mevalonate-derived isoprenoids. Although the… 
Highly Cited
1999
Highly Cited
1999
RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans*
A yeast two-hybrid screening for Ras-binding proteins in nematode Caenorhabditis elegans has identified a guanine nucleotide… 
Highly Cited
1997
Highly Cited
1997
Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal Region Interferes with Ras-dependent Activation of Raf-1*
Raf-1 is a major downstream effector of mammalian Ras. Binding of the effector domain of Ras to the Ras-binding domain of Raf-1… 
Highly Cited
1992
Highly Cited
1992
Subcellular distribution of the Rap1A protein in human neutrophils: colocalization and cotranslocation with cytochrome b559.
Rap1A, a low molecular weight guanosine triphosphate-binding protein (LMWG), has been shown previously by us to be associated… 
Highly Cited
1991
Highly Cited
1991
Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils.
The Ras-related protein, Rap1B, has previously been shown to serve as a PKA substrate in vitro and to be phosphorylated by cAMP… 
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