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Multiple roles of phosphoinositide-specific phospholipase C isozymes.
Phosphoinositide-specific phospholipase C is an effector molecule in the signal transduction process. It generates two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol fromExpand
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Genetic analysis of yeast RAS1 and RAS2 genes
We present a genetic analysis of RAS1 and RAS2 of S. cerevisiae, two genes that are highly homologous to mammalian ras genes. By constructing in vitro ras genes disrupted by selectable genes andExpand
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Regulation of a Novel Human Phospholipase C, PLCε, through Membrane Targeting by Ras*
Phosphoinositide-specific phospholipase C (PI-PLC) plays a pivotal role in regulation of intracellular signal transduction from various receptor molecules. More than 10 members of human PI-PLCExpand
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Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase Cε
Phospholipase Cε is a phosphoinositide-specific phospholipase C that selectively associates with Ras and Rap small GTPases as a target. Here we explored the molecular basis of the Rap1- as well asExpand
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DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth
The nucleic acid fraction from cells of 6 species of bacterium and 2 kinds of vertebrate, calf and salmon, was extracted and purified by the same procedures as described previously. When the spleenExpand
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Synthetic Oligonucleotides with Particular Base Sequences from the cDNA Encoding Proteins of Mycobacterium bovis BCG Induce Interferons and Activate Natural Killer Cells
Thirteen kinds of 45‐mer single‐stranded oligonucleotide, having sequence randomly selected from the known cDNA encoding BCG proteins, were tested for their capability to augment natural killer (NK)Expand
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Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling.
Phospholipase Cepsilon (PLCepsilon) is a novel class of phosphoinositide-specific PLC characterized by possession of CDC25 homology and Ras/Rap1-associating domains. We and others have shown thatExpand
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Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.
Phosphoinositide-specific phospholipase C (PI-PLC) plays a pivotal role in regulation of intracellular signal transduction from various receptor molecules. More than 10 members of human PI-PLCExpand
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Phospholipase Cɛ regulates ovulation in Caenorhabditis elegans
Abstract Phospholipase Cɛ (PLCɛ) is a novel class of phosphoinositide-specific PLC with unknown physiological functions. Here, we present the first genetic analysis of PLCɛ in an intact organism, theExpand
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DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase
We have cloned CYR1, the S. cerevisiae gene encoding adenylate cyclase. The DNA sequence of CYR1 can encode a protein of 2026 amino acids. This protein would contain a central region comprised ofExpand
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