• Publications
  • Influence
Nitric oxide and macrophage function.
TLDR
Although the high-output NO pathway probably evolved to protect the host from infection, suppressive effects on lymphocyte proliferation and damage to other normal host cells confer upon NOS2 the same protective/destructive duality inherent in every other major component of the immune response. Expand
Neutrophils and immunity: challenges and opportunities
  • C. Nathan
  • Biology, Medicine
  • Nature Reviews Immunology
  • 1 March 2006
TLDR
Neutrophils inform and shape immune responses, contribute to the repair of tissue as well as its breakdown, use killing mechanisms that enrich the concepts of specificity, and offer exciting opportunities for the treatment of neoplastic, autoinflammatory and autoimmune disorders. Expand
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages
TLDR
The microbial transcriptome served as a bioprobe of the MTB phagosomal environment, showing it to be nitrosative, oxidative, functionally hypoxic, carbohydrate poor, and capable of perturbing the pathogen's cell envelope. Expand
Points of control in inflammation
  • C. Nathan
  • Biology, Medicine
  • Nature
  • 19 December 2002
TLDR
The non-inflammatory state does not arise passively from an absence of inflammatory stimuli; rather, maintenance of health requires the positive actions of specific gene products to suppress reactions to potentially inflammatory stimuli that do not warrant a full response. Expand
Nitric oxide synthases: Roles, tolls, and controls
TLDR
The next ten years will bring forth evidence that NO is produced in slime molds, locusts, beetles, horseshoe crabs, mollusks, chickens, mice, rats, cows, and humans, and its physiologic roles will be at least as protean as those discovered for corticosteroids in the 194Os- 1980s. Expand
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
TLDR
Reporter constructs containing truncated promoter regions revealed that activation of NF-kappa B/Rel is critical in the induction of iNOS by LPS, however, additional, newly synthesized proteins contribute to the NF- kappa Bd-dependent transcription factor complex on the iN OS promoter in LPS-treated mouse macrophages. Expand
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
TLDR
Testing as a sole agent, IFN-gamma was the only one of the 12 cytokines capable of inducing both NO2- and H2O2 release and the pathways leading to secretion of H2 O2 and No2- are independent. Expand
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens.
  • C. Nathan, M. Shiloh
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 August 2000
TLDR
This review summarizes recent evidence from knock-out mice on the role of reactive oxygen intermediates and reactive nitrogen intermediates (RNI) in mammalian immunity and identifies candidates for RNI-resistance genes in Mycobacterium tuberculosis and other pathogens. Expand
Regulation of biosynthesis of nitric oxide.
  • C. Nathan, Q. Xie
  • Medicine, Biology
  • The Journal of biological chemistry
  • 13 May 1994
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
TLDR
This work cloned a 1,749-bp fragment from the 5'-flanking region of the iNOS gene, and used S1 nuclease mapping and primer extension to identify the mRNA transcription start site within it, which conferred synergistic inducibility by IFN-gamma plus LPS. Expand
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