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RAP1A gene

Known as: RAP1A, Member of RAS Oncogene Family Gene, RAS-RELATED PROTEIN 1A, RAP1A, member of RAS oncogene family 
This gene plays a role in signal transduction and cell adhesion.
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
The small GTPase Rap is best characterized as a critical regulator of integrin-mediated cell adhesion, although its mechanism of… Expand
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Highly Cited
2002
Highly Cited
2002
T cell receptor (TCR) stimulation activates the small GTPase Rap1A, which is reported to antagonize Ras signaling and induces T… Expand
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Highly Cited
1999
Highly Cited
1999
Cavernous angiomas are vascular malformations mostly located in the central nervous system and characterized by enlarged… Expand
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Highly Cited
1999
Highly Cited
1999
Rap1A is phosphorylated by cAMP-dependent protein kinase (PKA), and this phosphorylation has been shown to modulate its… Expand
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Highly Cited
1997
Highly Cited
1997
Krev-1/rap1A is an evolutionarily conserved Ras-family GTPase whose cellular function remains unclear, but which has been… Expand
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Highly Cited
1997
Highly Cited
1997
Raf-1 is a major downstream effector of mammalian Ras. Binding of the effector domain of Ras to the Ras-binding domain of Raf-1… Expand
Highly Cited
1996
Highly Cited
1996
The interactions of H-Ras, R-Ras, and Rap1A with the Ras-binding domains (RBD) of the c-Raf kinase and of the Ral guanine… Expand
Highly Cited
1995
Highly Cited
1995
Studies of neutrophil nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation in a cell-free system showed that… Expand
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Highly Cited
1994
Highly Cited
1994
Among the small GTPases of the Ras family, Rap proteins exhibit the highest homology with p21Ras. The four Rap proteins so far… Expand
Highly Cited
1992
Highly Cited
1992
The Saccharomyces cerevisiae ras-like gene RSR1 is particularly closely related to the mammalian gene Krev-1 (also known as… Expand