• Publications
  • Influence
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
TLDR
With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate RhoGTPases within particular spatio-temporal contexts. Expand
The Ras superfamily at a glance
TLDR
The Ras superfamily of small guanosine triphosphatases (GTPases) comprise over 150 human members, with evolutionarily conserved orthologs found in Drosophila, C. elegans, S. cerevisiae, Dictyostelium and plants. Expand
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
TLDR
The current status of the different approaches and targets that are under evaluation and development for the therapeutic intervention of this key signaling pathway in human disease are summarized. Expand
Drugging the undruggable RAS: Mission Possible?
TLDR
This Review summarizes the progress and the promise of five key approaches for the development of RAS-inhibitory molecules and addresses the issue of whether blocking RAS membrane association is a viable approach. Expand
Increasing complexity of Ras signaling
TLDR
Current understanding of Ras signal transduction is summarized with an emphasis on new complexities associated with the recognition and/or activation of cellular effectors, and the diverse array of signaling pathways mediated by interaction between Ras and Ras-subfamily proteins with multiple effectors. Expand
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
TLDR
H-RasV12-induced transformation can lead to the production of ·O2− through one or more pathways involving a flavoprotein and Rac1, suggesting a possible mechanism for the effects of antioxidants against Ras-induced cellular transformation. Expand
Rho-family GTPases: it's not only Rac and Rho (and I like it)
TLDR
The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases, and newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation. Expand
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
TLDR
These findings implicate activation of Ras function as an important component in BCR-ABL-mediated transformation and demonstrate that GRB-2 not only functions in normal development and mitogenesis but also plays a role in oncogenesis. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
TLDR
Data support the possibility that oncogenic Ras activation of Rac1 and RhoA, coupled with activation of the Raf/MAPK pathway, is required to trigger the full morphogenic and mitogenic consequences of oncogen Ras transformation. Expand
...
1
2
3
4
5
...