• Publications
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ras oncogenes in human cancer: a review.
  • J. Bos
  • Biology, Medicine
  • Cancer research
  • 1 September 1989
It appeared that ras gene mutations can be found in a variety of tumor types, although the incidence varies greatly and some evidence that environmental agents may be involved in the induction of the mutations. Expand
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
The cloned gene encoding a guanine-nucleotide-exchange factor (GEF) for Rap1 is named Epac, which contains a cAMP-binding site and a domain that is homologous to domains of known GEFs for Ras and Rap1 that is regulated directly by cAMP. Expand
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
It is shown that the PKB-regulated Forkhead transcription factor FOXO3a (also known as FKHR-L1) protects quiescent cells from oxidative stress by directly increasing their quantities of manganese superoxide dismutase messenger RNA and protein. Expand
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
A novel cAMP analogue is developed, 8CPT-2Me-cAMP, which activates Epac, but not PKA, both in vitro and in vivo, and tests the widespread model that Rap1 mediates cAMP-induced regulation of the extracellular signal-regulated kinase (ERK). Expand
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
GEFs and GAPs are multidomain proteins that are regulated by extracellular signals and localized cues that control cellular events in time and space and are potential therapeutic targets for developing drugs to treat various diseases, including cancer. Expand
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
It is concluded that AFX-like proteins are involved in cell-cycle regulation and that inactivation of these proteins is an important step in oncogenic transformation. Expand
Epac: a new cAMP target and new avenues in cAMP research
  • J. Bos
  • Chemistry, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 September 2003
Structural analysis of the cAMP-binding domains of Epac2 has identified a unifying mechanism for how cAMP activates proteins, and the design and synthesis of an Epac-specific cAMP analogue has paved the way for future discoveries. Expand
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
A homeostasis mechanism for sustaining cellular reactive oxygen species that is controlled by signalling pathways that can convey both negative (PI‐3K/PKB) and positive (Ras/Ral) inputs is outlined. Expand
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
A major pathway by which amino acids control mTOR signaling is distinct from that of insulin and that, instead of signaling through components of the insulin/class 1PI3K pathway, amino acids mediate mTOR activation by signaling through class 3 PI3K, hVps34. Expand