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RAP1A wt Allele

Known as: RAP1A, Member of RAS Oncogene Family wt Allele, KREV1, KREV-1 
Human RAP1A wild-type allele is located in the vicinity of 1p13.3 and is approximately 174 kb in length. This allele, which encodes Ras-related… 
National Institutes of Health

Related topics

Related topics

8 relations
1p13.3Focal adhesion pathwayHepatocyte Growth Factor Receptor Signaling PathwayHomo sapiens

Broader (1)

RAP1A gene

Papers overview

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1996
1996
Expression of human Krev‐1 gene in lungs of transgenic mice and subsequent reduction in multiplicity of ethyl carbamate‐induced lung adenomas
Mice of the A/J strain are useful models of lung cancer because they develop tumors spontaneously or after treatment with ethyl… 
1994
1994
Partial growth suppression of human prostate cancer cells by the Krev‐1 suppressor gene
A series of functional studies were performed to assess the potential role of the ras‐related transformation suppressor gene… 
1993
1993
Mapping of the KREV1 transformation suppressor gene and its pseudogene (KREV1P) to human chromosome 1p13.3 and 14q24.3, respectively, by fluorescence in situ hybridization.
The chromosomal location of the transformation suppressor gene KREV1 and its pseudogene (KREV1P) on R-banded human prometaphase… 
Highly Cited
1992
Highly Cited
1992
Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein
While the Ras C-terminal CAAX sequence signals modification by a 15-carbon farnesyl isoprenoid, the majority of isoprenylated… 
1992
1992
Loss of heterozygosity at the human RAP1A/Krev-1 locus is a rare event in colorectal tumors.
Kirsten-ras-revertant-1 (Krev-1/Rap1A) is a recently identified tumor suppressor gene which induces flat revertants when… 
1992
1992
Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
We found deletions of both alleles of the retinoblastoma gene (Rb) and the candidate Wilms' tumor gene (WT33) in a surgically… 
1991
1991
Krev-1: the first transformation suppressor gene isolated by expression cloning.
  • G. Klein
  • Japanese journal of cancer research : Gann
  • 1991
  • Corpus ID: 45558958
Highly Cited
1990
Highly Cited
1990
Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.
Krev-1 is an anti-oncogene that was originally identified by its ability to induce morphologic reversion of ras-transformed cells… 
1990
1990
Molecular cloning of rat Krev-1 cDNA and analysis of the mRNA levels in normal and NMU-induced mammary carcinomas.
Human Krev-1 has been reported to reverse the transformed phenotype in a variety of cell types containing activated ras. Most… 
Review
1989
Review
1989
[ras p21-like small MW GTP-binding proteins in transmembrane signaling].
We have separated multiple GTP-binding proteins (G proteins) having Mr values of about 20,000 (small MW G proteins) from bovine… 
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