Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form

@article{Mitra2003Rap1AAR,
  title={Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form},
  author={Raj S. Mitra and Zhaocheng Zhang and Bradley Stephen Henson and David M. Kurnit and Thomas E. Carey and Nisha J D'silva},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={6243-6256}
}
We recently showed that rap1 regulates growth and proliferation in normal keratinocytes, which provoked us to investigate its expression and regulation in malignant cells. Rap1 is variably expressed in whole cell lysates of squamous cell carcinoma (SCC) cell lines. Immunoblot analysis of nuclear and cytosolic fractions and immunohistochemistry revealed that in addition to cytoplasmic expression, SCC cells also exhibit prominent punctate rap1 expression in the nucleus. This unexpected nuclear… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 10 references

Head and Neck Tumor Cell Lines

  • Carey TE.
  • in. Atlas of Human Tumor Cell Lines. R. Hay, A.G…
  • 1994
Highly Influential
5 Excerpts

Proc

  • EG Lapetina, JC Lacal, BR Reep, L. Molina y Vedia
  • Natl. Acad. Sci. USA, 86, 3131–3134.
  • 1989
Highly Influential
4 Excerpts

Nat

  • H Habelhah, K Shah, +5 authors Z. Ronai
  • Cell Biol., 3, 325–330.
  • 2001
1 Excerpt

Cell, 89, 73–82

  • PJ.
  • Wagner AC and Williams JA. (1994). Am. J. Physiol…
  • 1997

Eur

  • F.
  • J. Cell Biol., 69, 224–235. Pizon V, Desjardins M…
  • 1996

Crit

  • HH Grunicke, K. Maly
  • Rev. Oncog., 4, 389–402.
  • 1993
2 Excerpts

Nature, 365, 661–663

  • MS Moore, G. Blobel
  • Noda M. (1993). Biochim. Biophys. Acta, 1155, 97…
  • 1993
2 Excerpts

J

  • I Maridonneau-Parini, J. de Gunzburg
  • Biol. Chem., 267, 6396–6402.
  • 1992

Br

  • AR Mehta, NW Johnson, MG. Deo
  • J.
  • 1991

Annu

  • M. Barbacid
  • Rev. Biochem., 56, 779–827. Beranger F, Goud B…
  • 1987
2 Excerpts

Similar Papers

Loading similar papers…