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Protriptyline

Known as: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine, 3-(5H-Dibenzo[a,D]cyclohepten-5-yl)-N-methyl-1-propanamine, Protriptylinum 
Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.
National Institutes of Health

Related topics

Related topics

21 relations

Narrower (3)

10,11-dihydro-10,11-dihydroxyprotriptylineProtriptyline HydrochlorideVivactil

Broader (3)

Adrenergic Uptake InhibitorsTricyclic Antidepressive Agentscycloheptane
Affective Disorders, PsychoticAntidepressive AgentsDepressive disorderDrug Allergy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Differential pattern of neuroprotection in lumbar, cervical and thoracic spinal cord segments in an organotypic rat model of glutamate-induced excitotoxicity
2005
2005
Direct, two-step synthetic pathway to novel dibenzo[a,c]phenanthridines.
Novel dibenzo[a,c]phenanthridines are prepared regioselectively by the application of a straightforward synthetic pathway… 
Highly Cited
1999
Highly Cited
1999
Site-specific NMDA receptor antagonists produce differential effects on cocaine self-administration in rats.
Highly Cited
1995
Highly Cited
1995
Identification and quantitation of dibenzo[a,l]pyrene--DNA adducts formed by rat liver microsomes in vitro: preponderance of depurinating adducts.
Dibenzo[a,l]pyrene (DB[a,l]P) is the most potent carcinogen known among aromatic hydrocarbons. DB[a,l]P-11,12-dihydrodiol… 
Highly Cited
1993
Highly Cited
1993
In vitro and in vivo studies with a series of hexapeptide endothelin antagonists.
The effects of different amino acids incorporated into the 16 and 17 positions of the C-terminal hexapeptide of ET-1 were… 
Highly Cited
1990
Highly Cited
1990
Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists.
A series of 73 dibenzo[a,d]cycloalkenimines were synthesized and evaluated for their ability to displace (+)-10,11-dihydro-5… 
Highly Cited
1989
Highly Cited
1989
A comparison of the anticonvulsant effects of competitive and non-competitive antagonist of the N-methyl-d-aspartate receptor
Highly Cited
1976
Highly Cited
1976
Plasma Concentrations of Protriptyline and Clinical Effects in Depressed Women
Summary We studied the relationship between side effects, clinical outcome and the drug plasma levels in 28 female depressed… 
1975
1975
Toxicity of tricyclic antidepressants to isolated rat hepatocytes.
Highly Cited
1967
Highly Cited
1967
The effect of beta-phenylethylamine on central and peripheral monoamine-containing neurons.
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